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Tbio
BPIFB2
BPI fold-containing family B member 2

Protein Summary
Description
This gene encodes a member of the lipid transfer/lipopolysaccharide binding protein (LT/LBP) gene family. It is highly expressed in hypertrophic tonsils. This gene and three other members of the LT/LBP gene family form a cluster on the long arm of chromosome 20. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000170150
  • ENSP00000170150
  • ENSG00000078898

Symbol
  • BPIL1
  • C20orf184
  • LPLUNC2
  • RYSR
  • BPIL1
  • LPLUNC2
  • C20orf184
  • dJ726C3.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.51
tissue sample
0.43
chemical
0.41
protein domain
0.41
protein complex
0.4


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.18   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.18   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
non-melanoma skin carcinoma
1
1
0
1.3
56.2
alcohol consumption measurement
1
1
1
24.5
1
1
1
13.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
non-melanoma skin carcinoma
0
1.3
56.2
alcohol consumption measurement
1
24.5
1
13.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BPI fold containing family B member 2
VGNC:6057
469916
Mouse
MGI:1913807
66557
Rat
RGD:1310866
296290
Dog
BPI fold containing family B member 2
VGNC:38508
485834
Horse
BPI fold containing family B member 2
VGNC:15869
100068763
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BPI fold containing family B member 2
Mouse
Rat
Dog
BPI fold containing family B member 2
Horse
BPI fold containing family B member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N4F0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (133)
1 – 10 of 133
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999996823
p_ni:  6e-8
p_wrong:  0.000003117
Score:  0.179
Data Source:  BioPlex,STRINGDB
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.999059881
p_ni:  9.2e-8
p_wrong:  0.000940028
Score:  0.189
Data Source:  BioPlex,STRINGDB
FGG
Tbio
Novelty:  0.00404457
Score:  0.965
Data Source:  STRINGDB
FGA
Tbio
Novelty:  0.00107227
Score:  0.959
Data Source:  STRINGDB
AHSG
Tbio
Novelty:  0.00112502
Score:  0.953
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.952
Data Source:  STRINGDB
AFP
Tbio
Novelty:  0.00004755
Score:  0.951
Data Source:  STRINGDB
IGFBP1
Tchem
Novelty:  0.0006975
Score:  0.948
Data Source:  STRINGDB
ITIH2
Tbio
Novelty:  0.04886358
Score:  0.943
Data Source:  STRINGDB
APOB
Tchem
Novelty:  0.00008247
Score:  0.935
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5.18

PubMed score by year
PubTator Score  3.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer