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Tchem
MINK1
Misshapen-like kinase 1

Protein Summary
Description
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347992
  • ENSP00000269296
  • ENSG00000141503
  • ENST00000355280
  • ENSP00000347427
  • ENST00000453408
  • ENSP00000406487

Symbol
  • B55
  • MAP4K6
  • MINK
  • YSK2
  • ZC3
  • B55
  • ZC3
  • MINK
  • YSK2
  • MAP4K6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
small molecule
0.92
transcription factor perturbation
0.88
protein domain
0.85
kinase perturbation
0.84


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.66   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.66   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 41
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
7
8
4.2
98.7
mean platelet volume
3
5
7
96.6
platelet crit
2
3
3
92.4
sphingomyelin measurement
1
3
7
89.7
blood metabolite measurement
2
2
2
89
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
8
4.2
98.7
mean platelet volume
7
96.6
platelet crit
3
92.4
sphingomyelin measurement
7
89.7
blood metabolite measurement
2
89
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
misshapen like kinase 1
VGNC:9598
454455
Macaque
misshapen like kinase 1
721582
Mouse
MGI:1355329
50932
Rat
RGD:1359135
303259
Dog
misshapen like kinase 1
VGNC:53424
100686834
Species
Name
OMA
EggNOG
Inparanoid
Chimp
misshapen like kinase 1
Macaque
misshapen like kinase 1
Mouse
Rat
Dog
misshapen like kinase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N4C8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Oxidative Stress Induced Senescence
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Oxidative Stress Induced Senescence
Gene Ontology Terms (30)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (88)
1 – 10 of 88
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.99999989
p_ni:  1e-7
p_wrong:  9e-9
Score:  0.523
Data Source:  BioPlex,STRINGDB
NANOS2
Tbio
Novelty:  0.01489157
p_int:  0.999994834
p_ni:  0.000004268
p_wrong:  8.98e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
TEX264
Tbio
Novelty:  0.32406417
p_int:  0.999988068
p_ni:  0.000004114
p_wrong:  0.000007818
Score:  0.161
Data Source:  BioPlex,STRINGDB
PPP1R15A
Tchem
Family:  Enzyme
Novelty:  0.00529607
p_int:  0.999945172
p_ni:  0.000054782
p_wrong:  4.6e-8
Score:  0.374
Data Source:  BioPlex,STRINGDB
SLC9A8
Tbio
Family:  Transporter
Novelty:  0.03305341
p_int:  0.999942469
p_ni:  0.000057522
p_wrong:  9e-9
Data Source:  BioPlex
TSEN15
Tbio
Family:  Enzyme
Novelty:  0.17606559
p_int:  0.999851786
p_ni:  0.000058409
p_wrong:  0.000089805
Score:  0.209
Data Source:  BioPlex,STRINGDB
NCK1
Tbio
Novelty:  0.00352084
p_int:  0.999498122
p_ni:  0.000469881
p_wrong:  0.000031996
Score:  0.8
Data Source:  BioPlex,STRINGDB
STRN
Tbio
Novelty:  0.01025814
p_int:  0.999163036
p_ni:  0.000831804
p_wrong:  0.00000516
Score:  0.691
Data Source:  BioPlex,STRINGDB
STRN3
Tbio
Novelty:  0.10331283
p_int:  0.99883774
p_ni:  0.00115667
p_wrong:  0.00000559
Score:  0.511
Data Source:  BioPlex,STRINGDB
ATG14
Tbio
Novelty:  0.00914791
p_int:  0.991641756
p_ni:  0.007868286
p_wrong:  0.000489958
Data Source:  BioPlex
Publication Statistics
PubMed Score  195.66

PubMed score by year
PubTator Score  39.23

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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