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Tbio
PHETA1
Sesquipedalian-1

Protein Summary
Description
Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane. This gene encodes a protein that localizes to the endosome and interacts with the enzyme, inositol polyphosphate 5-phosphatase OCRL-1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361483
  • ENSP00000354461
  • ENSG00000198324
  • ENST00000547838
  • ENSP00000447353
  • ENST00000548163
  • ENSP00000449994

Symbol
  • FAM109A
  • SES1
  • FAM109A
  • IPIP27A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
cell type or tissue
0.73
virus perturbation
0.64
cellular component
0.63
cell line
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.62   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.62   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (107)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
7
7
7
5.3
99.7
high density lipoprotein cholesterol measurement
5
5
7
98.5
platelet crit
2
3
4
98.2
reticulocyte count
7
3
9
97.7
lymphocyte count
3
2
3
96.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
7
5.3
99.7
high density lipoprotein cholesterol measurement
7
98.5
platelet crit
4
98.2
reticulocyte count
9
97.7
lymphocyte count
3
96.1
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2442708
231717
Rat
RGD:1310656
288664
Dog
PH domain containing endocytic trafficking adaptor 1
VGNC:52931
Cow
PH domain containing endocytic trafficking adaptor 1
VGNC:28714
785809
Pig
family with sequence similarity 109 member A
100156507
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
PH domain containing endocytic trafficking adaptor 1
Cow
PH domain containing endocytic trafficking adaptor 1
Pig
family with sequence similarity 109 member A
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8N4B1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (33)
1 – 10 of 33
INPP5B
Tbio
Family:  Enzyme
Novelty:  0.02981249
p_int:  0.99999996
p_ni:  3.8e-8
p_wrong:  1e-9
Score:  0.967
Data Source:  BioPlex,STRINGDB
CARD9
Tbio
Family:  Enzyme
Novelty:  0.00547101
p_int:  0.999999357
p_ni:  6.43e-7
Score:  0.251
Data Source:  BioPlex,STRINGDB
PLEKHJ1
Tdark
Novelty:  1.44399298
p_int:  0.99999413
p_ni:  1.2e-7
p_wrong:  0.000005751
Score:  0.933
Data Source:  BioPlex,STRINGDB
OCRL
Tbio
Family:  Enzyme
Novelty:  0.00555539
p_int:  0.999988829
p_ni:  0.000011171
Score:  0.995
Data Source:  BioPlex,STRINGDB
GPX7
Tbio
Family:  Enzyme
Novelty:  0.01342855
p_int:  0.998449137
p_ni:  0.000006646
p_wrong:  0.001544217
Score:  0.537
Data Source:  BioPlex,STRINGDB
SPG7
Tbio
Family:  Enzyme
Novelty:  0.00463357
p_int:  0.947207147
p_ni:  0.052792853
p_wrong:  1e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
PHETA2
Tbio
Novelty:  2.16796164
Score:  0.793
Data Source:  STRINGDB
CUX2
Tbio
Family:  TF
Novelty:  0.02004476
Score:  0.64
Data Source:  STRINGDB
TSPEAR
Tbio
Novelty:  0.15908638
Score:  0.623
Data Source:  STRINGDB
TMEM116
Tdark
Novelty:  1.81767497
Score:  0.576
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2.62

PubMed score by year
PubTator Score  0.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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