Tbio PNKD Probable hydrolase PNKD

Protein Summary

Description

Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway. This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q8N490
• A8K1F2
• Q96A48
• Q9BU26
• Q9NSX4
• Q9ULN6
• Q9Y4T1

Gene Name

• PNKD

Ensembl ID

• ENST00000248451
• ENSP00000248451
• ENSG00000127838
• ENST00000258362
• ENSP00000258362
• ENST00000273077
• ENSP00000273077
• ENST00000436005
• ENSP00000414400

Symbol

• KIAA1184
• MR1
• TAHCCP2
• MR1
• PDC
• DYT8
• FPD1
• MR-1
• BRP17
• MR-1S
• PKND1
• PNKD1
• FKSG19
• TAHCCP2
• KIPP1184

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.9
transcription factor binding site profile	0.88
disease perturbation	0.87
transcription factor perturbation	0.8
virus perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.28   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 119   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.28   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0