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Tchem
SFRP1
Secreted frizzled-related protein 1

Protein Summary
Description
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220772
  • ENSP00000220772
  • ENSG00000104332

Symbol
  • FRP
  • FRP1
  • SARP2
  • FRP
  • FRP1
  • FrzA
  • FRP-1
  • SARP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
1
molecular function
0.91
transcription factor perturbation
0.88
biological term
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 410.27   (req: < 5)
Gene RIFs: 158   (req: <= 3)
Antibodies: 348   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 410.27   (req: >= 5)
Gene RIFs: 158   (req: > 3)
Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 88
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 66
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
2
35
HbA1c measurement
1
1
1
7.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
2
35
HbA1c measurement
1
7.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
secreted frizzled related protein 1
VGNC:10329
736186
Macaque
secreted frizzled related protein 1
702876
Mouse
MGI:892014
20377
Rat
RGD:621074
84402
Dog
secreted frizzled related protein 1
VGNC:46080
482844
Species
Name
OMA
EggNOG
Inparanoid
Chimp
secreted frizzled related protein 1
Macaque
secreted frizzled related protein 1
Mouse
Rat
Dog
secreted frizzled related protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N474-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (17)
Negative regulation of TCF-dependent signaling by WNT ligand antagonists (R-HSA-3772470)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Gene Ontology Terms (96)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (135)
1 – 10 of 135
WNT1
Tbio
Novelty:  0.00124301
Score:  0.991
Data Source:  STRINGDB
WNT8B
Tbio
Novelty:  0.0140304
Score:  0.983
Data Source:  STRINGDB
WNT8A
Tbio
Novelty:  0.01404009
Score:  0.982
Data Source:  STRINGDB
WNT3A
Tchem
Novelty:  0.00119275
Score:  0.979
Data Source:  Reactome,STRINGDB
LRP5
Tbio
Novelty:  0.00089807
Score:  0.971
Data Source:  STRINGDB
LRP6
Tbio
Novelty:  0.00305615
Score:  0.969
Data Source:  STRINGDB
WNT4
Tbio
Novelty:  0.00276803
Score:  0.962
Data Source:  STRINGDB
WNT5A
Tbio
Novelty:  0.00125563
Score:  0.957
Data Source:  STRINGDB
WNT2
Tbio
Novelty:  0.00313614
Score:  0.939
Data Source:  STRINGDB
FZD2
Tbio
Family:  GPCR
Novelty:  0.00774893
Score:  0.929
Data Source:  STRINGDB
Publication Statistics
PubMed Score  410.27

PubMed score by year
PubTator Score  397.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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