You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
D2HGDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

Protein Summary
Description
Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate. This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321264
  • ENSP00000315351
  • ENSG00000180902

Symbol
  • D2HGD
  • D2HGD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.86
transcription factor binding site profile
0.79
gene perturbation
0.71
tissue sample
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.89   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.89   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
TIGIT
Tbio
Novelty:  0.0064542
p_int:  0.999998988
p_ni:  0.000001012
Data Source:  BioPlex
ZNF462
Tbio
Novelty:  0.13731082
p_int:  0.999668531
p_ni:  0.000331467
p_wrong:  2e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
RAB30
Tbio
Family:  Enzyme
Novelty:  0.1262404
p_int:  0.999581755
p_ni:  0.000418231
p_wrong:  1.5e-8
Data Source:  BioPlex
SDHB
Tchem
Family:  Enzyme
Novelty:  0.0010199
p_int:  0.995021694
p_ni:  0.004978306
Score:  0.404
Data Source:  BioPlex,STRINGDB
GLB1L3
Tdark
Family:  Enzyme
Novelty:  1.00833616
p_int:  0.993870203
p_ni:  0.006007331
p_wrong:  0.000122467
Data Source:  BioPlex
SLAMF1
Tbio
Novelty:  0.00112892
p_int:  0.993132086
p_ni:  0.00686245
p_wrong:  0.000005464
Data Source:  BioPlex
NUDT16
Tbio
Novelty:  0.06032864
p_int:  0.992003761
p_ni:  0.00748288
p_wrong:  0.000513359
Data Source:  BioPlex
TRMT1
Tbio
Family:  Enzyme
Novelty:  0.01795504
p_int:  0.987819633
p_ni:  0.002330262
p_wrong:  0.009850105
Score:  0.305
Data Source:  BioPlex,STRINGDB
DHRS4L2
Tbio
Family:  Enzyme
Novelty:  0.03296542
p_int:  0.985690443
p_ni:  0.005650948
p_wrong:  0.008658609
Score:  0.489
Data Source:  BioPlex,STRINGDB
YBEY
Tdark
Family:  Enzyme
Novelty:  0.02778029
p_int:  0.983290962
p_ni:  0.003128101
p_wrong:  0.013580937
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (R-HSA-880009)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
Reactome
Metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
Metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer antigen 125 measurement
1
5
5
97.9
6
2
2
1.1
90.7
eosinophil count
3
2
4
90.1
eosinophil percentage of leukocytes
2
2
3
89.5
blood protein measurement
1
1
1
86.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer antigen 125 measurement
5
97.9
2
1.1
90.7
eosinophil count
4
90.1
eosinophil percentage of leukocytes
3
89.5
blood protein measurement
1
86.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
D-2-hydroxyglutarate dehydrogenase
VGNC:50726
748707
Macaque
D-2-hydroxyglutarate dehydrogenase
702028
Mouse
MGI:2138209
98314
Rat
RGD:1307976
301624
Dog
D-2-hydroxyglutarate dehydrogenase
VGNC:39755
609641
Species
Name
OMA
EggNOG
Inparanoid
Chimp
D-2-hydroxyglutarate dehydrogenase
Macaque
D-2-hydroxyglutarate dehydrogenase
Mouse
Rat
Dog
D-2-hydroxyglutarate dehydrogenase
Publication Statistics
PubMed Score 25.89
PubMed score by year
PubTator Score 13.04
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title