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Tbio
GUF1
Translation factor GUF1, mitochondrial

Protein Classes
Protein Summary
Description
Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. This gene encodes a GTPase that triggers back-translocation of the elongating ribosome during mitochondrial protein synthesis. The protein contains a highly conserved C-terminal domain not found in other GTPases that facilitates tRNA binding. The encoded protein is thought to prevent misincorporation of amino acids in stressful, suboptimal conditions. An allelic variant in this gene has been associated with early infantile epileptic encephalopathy-40. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281543
  • ENSP00000281543
  • ENSG00000151806

Symbol
  • EF4
  • EF-4
  • EIEE40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.94
virus perturbation
0.85
histone modification site profile
0.82
interacting protein
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.89   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.89   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GUF1 homolog, GTPase
VGNC:2075
461197
Macaque
GUF1 homolog, GTPase
703333
Mouse
MGI:2140726
231279
Rat
RGD:1310774
305317
Dog
GUF1 homolog, GTPase
VGNC:49821
482127
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GUF1 homolog, GTPase
Macaque
GUF1 homolog, GTPase
Mouse
Rat
Dog
GUF1 homolog, GTPase
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (232)
1 – 10 of 232
MRPS7
Tbio
Novelty: 0.00153134
p_int: 0.999915877
p_ni: 0.000084119
p_wrong: 4e-9
Score: 0.869
Data Source: BioPlex,STRINGDB
LAMP2
Tbio
Novelty: 0.00168009
p_int: 0.997500616
p_ni: 0.002206477
p_wrong: 0.000292907
Data Source: BioPlex
OSTM1
Tbio
Novelty: 0.03033192
p_int: 0.996119105
p_ni: 0.003876125
p_wrong: 0.00000477
Data Source: BioPlex
FAM174A
Tdark
Novelty: 0.30693139
p_int: 0.995070632
p_ni: 0.004825708
p_wrong: 0.00010366
Data Source: BioPlex
TNF
Tclin
Novelty: 0.00001457
p_int: 0.979527956
p_ni: 0.019640972
p_wrong: 0.000831072
Score: 0.2
Data Source: BioPlex,STRINGDB
SLC22A15
Tdark
Family: Transporter
Novelty: 0.22792289
p_int: 0.975108235
p_ni: 0.024167658
p_wrong: 0.000724107
Data Source: BioPlex
C5AR2
Tbio
Family: GPCR
Novelty: 0.01193736
p_int: 0.97214318
p_ni: 0.026796187
p_wrong: 0.001060633
Data Source: BioPlex
MGARP
Tbio
Novelty: 0.02883753
p_int: 0.970087495
p_ni: 0.029360156
p_wrong: 0.00055235
Data Source: BioPlex
TMCO3
Tdark
Novelty: 1.16719823
p_int: 0.955694145
p_ni: 0.043866559
p_wrong: 0.000439296
Score: 0.158
Data Source: BioPlex,STRINGDB
TSPYL6
Tdark
Novelty: 0.68478376
p_int: 0.918362773
p_ni: 0.080864647
p_wrong: 0.00077258
Score: 0.155
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  229.89

PubMed score by year
PubTator Score  82.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer