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Tdark
SVOPL
Putative transporter SVOPL

Protein Summary
Description
The protein encoded by this gene is thought to be a member of solute carrier family 22, which includes transmembrane proteins that transport toxins and drugs from the body. This gene is a paralog of the SVOP gene that encodes synaptic vesicle 2-related protein. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288513
  • ENSP00000288513
  • ENSG00000157703
  • ENST00000419765
  • ENSP00000405482
  • ENST00000436657
  • ENSP00000417018
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
virus perturbation
0.64
tissue sample
0.61
cell line
0.55
cell type or tissue
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.7   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.7   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
FAM241A
Tdark
Novelty:  1.04041354
p_int:  0.998448068
p_ni:  0.001526619
p_wrong:  0.000025313
Data Source:  BioPlex
RTN4
Tbio
Novelty:  0.00080371
p_int:  0.994267043
p_ni:  0.005732957
Data Source:  BioPlex
RTN2
Tbio
Novelty:  0.05184418
p_int:  0.99326962
p_ni:  0.00670502
p_wrong:  0.00002536
Data Source:  BioPlex
SERPINE2
Tbio
Novelty:  0.00246375
p_int:  0.957432669
p_ni:  0.04252543
p_wrong:  0.000041901
Data Source:  BioPlex
LMF2
Tdark
Family:  Enzyme
Novelty:  0.24810125
p_int:  0.829350545
p_ni:  0.169321216
p_wrong:  0.00132824
Data Source:  BioPlex
SIDT2
Tbio
Novelty:  0.07560652
p_int:  0.792120965
p_ni:  0.01560507
p_wrong:  0.192273964
Data Source:  BioPlex
REEP6
Tbio
Novelty:  0.10645981
p_int:  0.786700299
p_ni:  0.101085684
p_wrong:  0.112214017
Data Source:  BioPlex
ARL6IP5
Tbio
Novelty:  0.00871985
p_int:  0.758838442
p_ni:  0.241161427
p_wrong:  1.31e-7
Data Source:  BioPlex
MFSD11
Tdark
Novelty:  0.13167358
Score:  0.816
Data Source:  STRINGDB
MFSD5
Tdark
Novelty:  0.58146966
Score:  0.801
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
2
39.6
sleep duration
1
1
2
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
39.6
sleep duration
2
39.6
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SVOP like
VGNC:8765
463763
Macaque
SVOP like
710319
Mouse
MGI:2444335
320590
Dog
SVOP like
VGNC:51828
482780
Horse
SVOP like
VGNC:23785
100066769
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SVOP like
Macaque
SVOP like
Mouse
Dog
SVOP like
Horse
SVOP like
Publication Statistics
PubMed Score 1.70
PubMed score by year
PubTator Score 0.92
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title