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Tbio
LILRB2
Leukocyte immunoglobulin-like receptor subfamily B member 2

Protein Classes
Protein Summary
Description
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042, PubMed:16455647). Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11875462, PubMed:12853576, PubMed:9548455, PubMed:9842885).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314446
  • ENSP00000319960
  • ENSG00000131042
  • ENST00000391746
  • ENSP00000375626
  • ENST00000391748
  • ENSP00000375628
  • ENST00000391749
  • ENSP00000375629
  • ENST00000434421
  • ENSP00000410117
  • ENST00000610886
  • ENSP00000482933
  • ENSG00000276146
  • ENST00000614225
  • ENSP00000480841
  • ENSG00000275463
  • ENST00000617341
  • ENSP00000484373
  • ENST00000617886
  • ENSP00000483553
  • ENST00000618392
  • ENSP00000480302
  • ENSG00000274513
  • ENST00000618705
  • ENSP00000481208
  • ENST00000619122
  • ENSP00000483478
  • ENST00000621020
  • ENSP00000483014

Symbol
  • ILT4
  • LIR2
  • MIR10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.73
cell line
0.69
cell type or tissue
0.68
co-expressed gene
0.61
PubMedID
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.86   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.86   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (225)
Items per page:
1 – 5 of 225
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
13
11
26
99.1
high density lipoprotein cholesterol measurement
13
11
26
99.1
high density lipoprotein cholesterol measurement
13
11
26
99.1
apolipoprotein A 1 measurement
2
5
5
97.6
apolipoprotein A 1 measurement
2
5
5
97.6
Items per page:
1 – 5 of 225
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
26
99.1
high density lipoprotein cholesterol measurement
26
99.1
high density lipoprotein cholesterol measurement
26
99.1
apolipoprotein A 1 measurement
5
97.6
apolipoprotein A 1 measurement
5
97.6
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8N423-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (43)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Mutant Phenotype (IMP)
ARUK-UCL
Protein-Protein Interactions (302)
1 – 10 of 302
LILRA3
Tdark
p_int:  0.999999999
p_wrong:  1e-9
Data Source:  BioPlex
LILRB4
Tbio
Novelty:  0.01443658
p_int:  0.785162863
p_ni:  1.6e-8
p_wrong:  0.214837121
Score:  0.601
Data Source:  BioPlex,STRINGDB
HLA-G
Tbio
Novelty:  0.0009462
Score:  0.998
Data Source:  STRINGDB
B2M
Tbio
Novelty:  0.00011248
Score:  0.99
Data Source:  Reactome,STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.977
Data Source:  STRINGDB
HLA-F
Tbio
Novelty:  0.01200285
Score:  0.973
Data Source:  STRINGDB
ITGAX
Tbio
Novelty:  0.00040471
Score:  0.967
Data Source:  STRINGDB
HLA-A
Tbio
Novelty:  0.00270731
Score:  0.966
Data Source:  STRINGDB
HLA-A
Tbio
Novelty:  0.00270731
Score:  0.966
Data Source:  STRINGDB
HLA-A
Tbio
Novelty:  0.00270731
Score:  0.966
Data Source:  STRINGDB
Publication Statistics
PubMed Score  196.86

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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