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Tbio
LILRB2
Leukocyte immunoglobulin-like receptor subfamily B member 2

Protein Summary
Description
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042, PubMed:16455647). Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11875462, PubMed:12853576, PubMed:9548455, PubMed:9842885).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314446
  • ENSP00000319960
  • ENSG00000131042
  • ENST00000391746
  • ENSP00000375626
  • ENST00000391748
  • ENSP00000375628
  • ENST00000391749
  • ENSP00000375629
  • ENST00000434421
  • ENSP00000410117
  • ENST00000610886
  • ENSP00000482933
  • ENSG00000276146
  • ENST00000614225
  • ENSP00000480841
  • ENSG00000275463
  • ENST00000617341
  • ENSP00000484373
  • ENST00000617886
  • ENSP00000483553
  • ENST00000618392
  • ENSP00000480302
  • ENSG00000274513
  • ENST00000618705
  • ENSP00000481208
  • ENST00000619122
  • ENSP00000483478
  • ENST00000621020
  • ENSP00000483014

Symbol
  • ILT4
  • LIR2
  • MIR10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.73
cell line
0.69
cell type or tissue
0.68
co-expressed gene
0.61
PubMedID
0.53


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.75   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 225.75   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0