SLC25A45
Solute carrier family 25 member 45
Protein Summary
SLC25A45 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]
- ENST00000294187
- ENSP00000294187
- ENSG00000162241
- ENST00000398802
- ENSP00000381782
- ENST00000527174
- ENSP00000435489
- ENST00000534028
- ENSP00000431769
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.87 | ||
cell type or tissue | 0.64 | ||
transcription factor perturbation | 0.61 | ||
cellular component | 0.56 | ||
transcription factor | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.34 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 35 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.34 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 35 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (20)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (1)
Components (2)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
creatinine measurement | 2 | 2 | 3 | 88.9 | |||||
glomerular filtration rate | 1 | 2 | 2 | 88.5 | |||||
uric acid measurement | 1 | 1 | 1 | 78.9 | |||||
BMI-adjusted hip circumference | 2 | 6 | 6 | 77.9 | |||||
serum alanine aminotransferase measurement | 2 | 2 | 1 | 7.3 | 69.6 | ||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
creatinine measurement | 3 | 88.9 | |||||
glomerular filtration rate | 2 | 88.5 | |||||
uric acid measurement | 1 | 78.9 | |||||
BMI-adjusted hip circumference | 6 | 77.9 | |||||
serum alanine aminotransferase measurement | 1 | 7.3 | 69.6 | ||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | solute carrier family 25 member 45 | VGNC:7750 | 451322 | |||||
Macaque | solute carrier family 25 member 45 | 716427 | ||||||
Mouse | MGI:2147731 | 107375 | ||||||
Rat | RGD:1589953 | 689625 | ||||||
Dog | solute carrier family 25 member 45 | 483740 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | solute carrier family 25 member 45 | |||||
Macaque | solute carrier family 25 member 45 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 25 member 45 | |||||
Publication Statistics
PubMed Score 1.34
PubMed score by year
PubTator Score 0.92
PubTator score by year
Related Publications
Text Mined References (9)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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