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Tdark
SLC25A45
Solute carrier family 25 member 45

Protein Summary
Description
SLC25A45 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294187
  • ENSP00000294187
  • ENSG00000162241
  • ENST00000398802
  • ENSP00000381782
  • ENST00000527174
  • ENSP00000435489
  • ENST00000534028
  • ENSP00000431769
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
cell type or tissue
0.64
transcription factor perturbation
0.61
cellular component
0.56
transcription factor
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.34   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 35   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.34   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
FRMD8
Tdark
Novelty:  0.39375892
Score:  0.791
Data Source:  STRINGDB
FAM174A
Tdark
Novelty:  0.30693139
Score:  0.759
Data Source:  STRINGDB
SLC25A35
Tdark
Family:  Transporter
Novelty:  1.19834062
Score:  0.693
Data Source:  STRINGDB
RNF186
Tbio
Novelty:  0.15621021
Score:  0.568
Data Source:  STRINGDB
TIGD3
Tdark
Novelty:  1.23642174
Score:  0.561
Data Source:  STRINGDB
ZNF785
Tdark
Family:  TF
Novelty:  0.42629766
Score:  0.543
Data Source:  STRINGDB
KDM2A
Tchem
Family:  Epigenetic
Novelty:  0.01990727
Score:  0.536
Data Source:  STRINGDB
SDHAF4
Tbio
Family:  Enzyme
Novelty:  0.24150488
Score:  0.529
Data Source:  STRINGDB
FAM89B
Tbio
Novelty:  0.10306021
Score:  0.527
Data Source:  STRINGDB
LTBP3
Tbio
Novelty:  0.0190763
Score:  0.492
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
2
2
3
88.9
glomerular filtration rate
1
2
2
88.5
uric acid measurement
1
1
1
78.9
BMI-adjusted hip circumference
2
6
6
77.9
serum alanine aminotransferase measurement
2
2
1
7.3
69.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
3
88.9
glomerular filtration rate
2
88.5
uric acid measurement
1
78.9
BMI-adjusted hip circumference
6
77.9
serum alanine aminotransferase measurement
1
7.3
69.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 45
VGNC:7750
451322
Macaque
solute carrier family 25 member 45
716427
Mouse
MGI:2147731
107375
Rat
RGD:1589953
689625
Dog
solute carrier family 25 member 45
483740
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 45
Macaque
solute carrier family 25 member 45
Mouse
Rat
Dog
solute carrier family 25 member 45
Publication Statistics
PubMed Score 1.34
PubMed score by year
PubTator Score 0.92
PubTator score by year
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Related Publications
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PMID
Year
Title