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Tbio
SDR16C5
Epidermal retinol dehydrogenase 2

Protein Summary
Description
Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH. This gene encodes a member of the short-chain alcohol dehydrogenase/reductase superfamily of proteins and is involved in the oxidation of retinol to retinaldehyde. The encoded protein is associated with the endoplasmic reticulum and is predicted to contain three transmembrane helices, suggesting that it is an integral membrane protein. It recognizes all-trans-retinol and all-trans-retinaldehyde as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303749
  • ENSP00000307607
  • ENSG00000170786
  • ENST00000396721
  • ENSP00000379947

Symbol
  • RDHE2
  • RDH#2
  • RDHE2
  • EPHD-2
  • RDH-E2
  • retSDR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.66
virus perturbation
0.5
tissue sample
0.49
cell line
0.46
chemical
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.62   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.62   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
4
7
97.7
body height
4
6
6
97.2
BMI-adjusted hip circumference
2
9
10
92.2
birth weight
2
2
2
62
heel bone mineral density
2
1
2
59.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
7
97.7
body height
6
97.2
BMI-adjusted hip circumference
10
92.2
birth weight
2
62
heel bone mineral density
2
59.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
short chain dehydrogenase/reductase family 16C member 5
VGNC:14584
472773
Macaque
short chain dehydrogenase/reductase family 16C member 5
696397
Mouse
MGI:2668443
242285
Rat
RGD:1565999
297805
Dog
short chain dehydrogenase/reductase family 16C member 5
VGNC:45955
477888
Species
Name
OMA
EggNOG
Inparanoid
Chimp
short chain dehydrogenase/reductase family 16C member 5
Macaque
short chain dehydrogenase/reductase family 16C member 5
Mouse
Rat
Dog
short chain dehydrogenase/reductase family 16C member 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N3Y7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
RA biosynthesis pathway (R-HSA-5365859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RA biosynthesis pathway
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Reactome
Signaling by Retinoic Acid
Name
Explore in Pharos
Explore in Source
RA biosynthesis pathway
Signal Transduction
Signaling by Nuclear Receptors
Signaling by Retinoic Acid
Protein-Protein Interactions (52)
1 – 10 of 52
FTH1
Tbio
Novelty:  0.000863
p_int:  0.999996445
p_ni:  0.000003278
p_wrong:  2.77e-7
Score:  0.212
Data Source:  BioPlex,STRINGDB
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.99998606
p_ni:  0.000013695
p_wrong:  2.45e-7
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.999982426
p_ni:  0.000017565
p_wrong:  8e-9
Score:  0.151
Data Source:  BioPlex,STRINGDB
ALDH1A3
Tchem
Family:  Enzyme
Novelty:  0.00691116
Score:  0.951
Data Source:  STRINGDB
RETSAT
Tdark
Family:  Enzyme
Novelty:  0.10624626
Score:  0.932
Data Source:  STRINGDB
ALDH1A1
Tchem
Family:  Enzyme
Novelty:  0.0012292
Score:  0.93
Data Source:  STRINGDB
ALDH1A2
Tchem
Family:  Enzyme
Novelty:  0.00461371
Score:  0.929
Data Source:  STRINGDB
RBP5
Tbio
Novelty:  0.06648663
Score:  0.929
Data Source:  STRINGDB
LRAT
Tbio
Family:  Enzyme
Novelty:  0.00593203
Score:  0.921
Data Source:  STRINGDB
BCO1
Tbio
Family:  Enzyme
Novelty:  0.00784197
Score:  0.915
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.62

PubMed score by year
PubTator Score  4.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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