You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FBXW8
F-box/WD repeat-containing protein 8

Protein Summary
Description
Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695). This gene encodes a member of the F- ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309909
  • ENSP00000310686
  • ENSG00000174989
  • ENST00000455858
  • ENSP00000389144

Symbol
  • FBW6
  • FBW8
  • FBX29
  • FBXO29
  • FBXW6
  • FBW6
  • FBW8
  • FBX29
  • FBXW6
  • FBXO29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
protein domain
0.85
transcription factor binding site profile
0.71
histone modification site profile
0.7
transcription factor
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.74   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.74   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (350)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999999316
p_ni:  6.83e-7
p_wrong:  1e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
ZNF669
Tdark
Family:  TF
Novelty:  2.09725685
p_int:  0.999993045
p_ni:  0.000006955
Score:  0.161
Data Source:  BioPlex,STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
p_int:  0.999991353
p_ni:  0.000008617
p_wrong:  3e-8
Score:  0.156
Data Source:  BioPlex,STRINGDB
CASQ2
Tbio
Novelty:  0.00775794
p_int:  0.999988782
p_ni:  0.000008842
p_wrong:  0.000002376
Data Source:  BioPlex
DGKG
Tbio
Family:  Enzyme
Novelty:  0.03666646
p_int:  0.999983976
p_ni:  0.000015332
p_wrong:  6.92e-7
Data Source:  BioPlex
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.999943298
p_ni:  0.0000567
p_wrong:  3e-9
Score:  0.377
Data Source:  BioPlex,STRINGDB
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.999940792
p_ni:  0.000059208
Score:  0.912
Data Source:  BioPlex,STRINGDB
TTC29
Tdark
Novelty:  0.1887357
p_int:  0.999935801
p_ni:  0.000063156
p_wrong:  0.000001043
Score:  0.198
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.999772508
p_ni:  0.000227491
Score:  0.358
Data Source:  BioPlex,STRINGDB
ZNF263
Tbio
Family:  TF
Novelty:  0.098799
p_int:  0.999727845
p_ni:  0.000272042
p_wrong:  1.13e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
3
90
hippocampal volume
4
2
0
59.1
82.7
platelet crit
1
1
1
66.3
brain volume measurement
1
2
0
52
65.4
hippocampal CA1 volume
1
1
0
24.1
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
90
hippocampal volume
0
59.1
82.7
platelet crit
1
66.3
brain volume measurement
0
52
65.4
hippocampal CA1 volume
0
24.1
36.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box and WD repeat domain containing 8
VGNC:13063
452285
Macaque
F-box and WD repeat domain containing 8
693388
Mouse
MGI:1923041
231672
Rat
RGD:1306032
304522
Dog
F-box and WD repeat domain containing 8
VGNC:40798
106557503
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box and WD repeat domain containing 8
Macaque
F-box and WD repeat domain containing 8
Mouse
Rat
Dog
F-box and WD repeat domain containing 8
Publication Statistics
PubMed Score 15.74
PubMed score by year
PubTator Score 10.31
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title