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Tbio
LCORL
Ligand-dependent nuclear receptor corepressor-like protein

Protein Summary
Description
May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity). This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326877
  • ENSP00000317566
  • ENSG00000178177
  • ENST00000382226
  • ENSP00000371661

Symbol
  • MLR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
transcription factor perturbation
0.84
histone modification site profile
0.8
transcription factor binding site profile
0.8
microRNA
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.33   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.33   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
3
4
99.2
body height
12
14
21
6.3
99.2
birth weight
6
5
6
99
corneal topography
2
1
2
93.4
sex hormone-binding globulin measurement
4
2
4
92.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
4
99.2
body height
21
6.3
99.2
birth weight
6
99
corneal topography
2
93.4
sex hormone-binding globulin measurement
4
92.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2651932
209707
Dog
ligand dependent nuclear receptor corepressor like [Source:HGNC Symbol;Acc:HGNC:30776]
Horse
ligand dependent nuclear receptor corepressor like
VGNC:51207
100068577
Cow
ligand dependent nuclear receptor corepressor like
VGNC:30816
540095
Pig
ligand dependent nuclear receptor corepressor like
100337668
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
ligand dependent nuclear receptor corepressor like [Source:HGNC Symbol;Acc:HGNC:30776]
Horse
ligand dependent nuclear receptor corepressor like
Cow
ligand dependent nuclear receptor corepressor like
Pig
ligand dependent nuclear receptor corepressor like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N3X6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (42)
1 – 10 of 42
CTBP1
Tbio
Novelty: 0.00243818
p_int: 0.999999981
p_wrong: 1.9e-8
Score: 0.429
Data Source: BioPlex,STRINGDB
NCAPG
Tbio
Novelty: 0.01777557
Score: 0.86
Data Source: STRINGDB
DCAF16
Tdark
Novelty: 0.35666992
Score: 0.795
Data Source: STRINGDB
BMP15
Tbio
Novelty: 0.00364888
Score: 0.757
Data Source: STRINGDB
PLAG1
Tbio
Family: TF
Novelty: 0.00665136
Score: 0.735
Data Source: STRINGDB
FAM184B
Tdark
Novelty: 0.23365805
Score: 0.734
Data Source: STRINGDB
LAP3
Tchem
Family: Enzyme
Novelty: 0.00327467
Score: 0.727
Data Source: STRINGDB
UBAP1
Tbio
Novelty: 0.02276845
Score: 0.665
Data Source: STRINGDB
CHCHD7
Tdark
Novelty: 0.03220354
Score: 0.619
Data Source: STRINGDB
MFSD6
Tbio
Novelty: 0.0161011
Score: 0.578
Data Source: STRINGDB
Publication Statistics
PubMed Score  37.33

PubMed score by year
PubTator Score  14.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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