Tbio STAG2 Cohesin subunit SA-2

Protein Summary

Description

Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• Q8N3U4
• B1AMT5
• D3DTF5
• O00540
• Q5JTI6
• Q68DE9
• Q9H1N8

Gene Name

• STAG2

Ensembl ID

• ENST00000218089
• ENSP00000218089
• ENSG00000101972
• ENST00000371144
• ENSP00000360186
• ENST00000371145
• ENSP00000360187
• ENST00000371157
• ENSP00000360199
• ENST00000371160
• ENSP00000360202

Symbol

• SA2
• SA2
• SA-2
• SCC3B
• NEDXCF
• bA517O1.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
transcription factor perturbation	0.88
cell type or tissue	0.84
ligand (protein) perturbation	0.83
transcription factor	0.76

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Cohesin Subunit Sa-2

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Cohesin Subunit Sa-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 311.82   (req: < 5)

Gene RIFs: 66   (req: <= 3)

Antibodies: 286   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 311.82   (req: >= 5)

Gene RIFs: 66   (req: > 3)

Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0