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Tbio
STAG2
Cohesin subunit SA-2

Protein Summary
Description
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218089
  • ENSP00000218089
  • ENSG00000101972
  • ENST00000371144
  • ENSP00000360186
  • ENST00000371145
  • ENSP00000360187
  • ENST00000371157
  • ENSP00000360199
  • ENST00000371160
  • ENSP00000360202

Symbol
  • SA2
  • SA2
  • SA-2
  • SCC3B
  • NEDXCF
  • bA517O1.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.88
cell type or tissue
0.84
ligand (protein) perturbation
0.83
transcription factor
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.42   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 286   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.42   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
50.7
mean corpuscular volume
1
1
1
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
50.7
mean corpuscular volume
1
46.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stromal antigen 2
VGNC:11630
473766
Mouse
MGI:1098583
20843
Rat
RGD:1562042
313304
Dog
stromal antigen 2
VGNC:46874
492111
Horse
stromal antigen 2
VGNC:23649
100055046
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stromal antigen 2
Mouse
Rat
Dog
stromal antigen 2
Horse
stromal antigen 2
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (60)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cohesin Loading onto Chromatin
Reactome
ESR-mediated signaling
Reactome
Establishment of Sister Chromatid Cohesion
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cohesin Loading onto Chromatin
ESR-mediated signaling
Establishment of Sister Chromatid Cohesion
Gene Ontology Terms (16)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (300)
1 – 10 of 300
RAD21
Tbio
Novelty: 0.00270936
p_int: 0.99999999
p_ni: 1e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
GPR183
Tchem
Family: GPCR
Novelty: 0.02005679
p_int: 0.999970769
p_ni: 0.000029231
Data Source: BioPlex
PNKD
Tbio
Family: Enzyme
Novelty: 0.02456078
p_int: 0.999774462
p_ni: 0.000225538
Data Source: BioPlex
CDCA5
Tbio
Novelty: 0.02255012
p_int: 0.999427535
p_ni: 0.000572465
Score: 0.985
Data Source: BioPlex,STRINGDB
SIGLECL1
Tdark
p_int: 0.997119026
p_ni: 0.002880974
Data Source: BioPlex
COMTD1
Tdark
Family: Enzyme
Novelty: 0.245971
p_int: 0.984132707
p_ni: 0.015867293
Data Source: BioPlex
REC8
Tbio
Novelty: 0.00732742
p_int: 0.941043027
p_ni: 0.058956906
p_wrong: 6.7e-8
Score: 0.988
Data Source: BioPlex,STRINGDB
CITED1
Tbio
Novelty: 0.01956689
p_int: 0.931932744
p_ni: 0.06806681
p_wrong: 4.46e-7
Data Source: BioPlex
SEMA4C
Tbio
Novelty: 0.01237067
p_int: 0.928080398
p_ni: 0.07191526
p_wrong: 0.000004342
Data Source: BioPlex
VSIG2
Tdark
Novelty: 0.32398032
p_int: 0.886614528
p_ni: 0.113385472
Data Source: BioPlex
Publication Statistics
PubMed Score  233.42

PubMed score by year
PubTator Score  111.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer