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Tbio
MPP5
MAGUK p55 subfamily member 5

Protein Summary
Description
May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261681
  • ENSP00000261681
  • ENSG00000072415
  • ENST00000555925
  • ENSP00000451488

Symbol
  • PALS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
kinase perturbation
0.93
histone modification site profile
0.86
cellular component
0.79
microRNA
0.78


Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.2   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 305   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.2   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 305   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
membrane palmitoylated protein 5
VGNC:10244
452978
Mouse
MGI:1927339
56217
Rat
RGD:1308071
314259
Dog
membrane palmitoylated protein 5
VGNC:43346
490740
Horse
membrane palmitoylated protein 5
VGNC:20292
100052602
Species
Name
OMA
EggNOG
Inparanoid
Chimp
membrane palmitoylated protein 5
Mouse
Rat
Dog
membrane palmitoylated protein 5
Horse
membrane palmitoylated protein 5
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8N3R9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Tight junction interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Tight junction interactions
Gene Ontology Terms (18)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (103)
1 – 10 of 103
LIN7C
Tbio
Novelty: 0.06778878
p_int: 1
Score: 0.943
Data Source: BioPlex,STRINGDB
MPDZ
Tbio
Novelty: 0.01656439
p_int: 0.999999995
p_ni: 5e-9
Score: 0.978
Data Source: BioPlex,STRINGDB
PATJ
Tbio
Novelty: 0.01420008
p_int: 0.999999993
p_ni: 7e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
AMOTL2
Tbio
Novelty: 0.04258164
p_int: 0.999999982
p_ni: 8e-9
p_wrong: 9e-9
Score: 0.605
Data Source: BioPlex,STRINGDB
RPH3A
Tbio
Family: Epigenetic
Novelty: 0.01321524
p_int: 0.999999901
p_ni: 9.8e-8
p_wrong: 1e-9
Score: 0.169
Data Source: BioPlex,STRINGDB
LIN7B
Tbio
Novelty: 0.12689192
p_int: 0.999998533
p_ni: 6.5e-8
p_wrong: 0.000001403
Score: 0.964
Data Source: BioPlex,STRINGDB
HOMER3
Tbio
Novelty: 0.04408998
p_int: 0.999987718
p_ni: 0.000012282
Score: 0.205
Data Source: BioPlex,STRINGDB
AMOTL1
Tbio
Novelty: 0.03842225
p_int: 0.999912818
p_ni: 0.000087182
Score: 0.84
Data Source: BioPlex,STRINGDB
FAM124A
Tdark
Novelty: 1.51577847
p_int: 0.999896639
p_ni: 0.000103361
Data Source: BioPlex
ALOX5
Tclin
Family: Enzyme
Novelty: 0.00062988
p_int: 0.999879806
p_ni: 0.000120194
Score: 0.189
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  60.20

PubMed score by year
PubTator Score  61.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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