Tbio MPP5 MAGUK p55 subfamily member 5

Protein Summary

Description

May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q8N3R9
• A1L380
• Q7Z631
• Q86T98
• Q8N7I5
• Q9H9Q0

Gene Name

• MPP5

Ensembl ID

• ENST00000261681
• ENSP00000261681
• ENSG00000072415
• ENST00000555925
• ENSP00000451488

Symbol

• PALS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
kinase perturbation	0.93
histone modification site profile	0.86
cellular component	0.79
microRNA	0.78

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Nucleotide Kinase / Maguk P55 Subfamily Member 5

Protein / Cell Junction Protein / Maguk P55 Subfamily Member 5

DTO Classes

Protein / Enzyme / Transferase / Maguk P55 Subfamily Member 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.81   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 305   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.81   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 305   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (103)

Explore Interacting Targets

1 – 10 of 103

• See Interactions on String-DB

LIN7C

Tbio

Novelty:  0.06778878

p_int:  1

Score:  0.943

Data Source:  BioPlex,STRINGDB

MPDZ

Tbio

Novelty:  0.01656439

p_int:  0.999999995

p_ni:  5e-9

Score:  0.978

Data Source:  BioPlex,STRINGDB

PATJ

Tbio

Novelty:  0.01420008

p_int:  0.999999993

p_ni:  7e-9

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

AMOTL2

Tbio

Novelty:  0.04258164

p_int:  0.999999982

p_ni:  8e-9

p_wrong:  9e-9

Score:  0.605

Data Source:  BioPlex,STRINGDB

RPH3A

Tbio

Family:  Epigenetic

Novelty:  0.01321524

p_int:  0.999999901

p_ni:  9.8e-8

p_wrong:  1e-9

Score:  0.169

Data Source:  BioPlex,STRINGDB

LIN7B

Tbio

Novelty:  0.12689192

p_int:  0.999998533

p_ni:  6.5e-8

p_wrong:  0.000001403

Score:  0.964

Data Source:  BioPlex,STRINGDB

HOMER3

Tbio

Novelty:  0.04408998

p_int:  0.999987718

p_ni:  0.000012282

Score:  0.205

Data Source:  BioPlex,STRINGDB

AMOTL1

Tbio

Novelty:  0.03842225

p_int:  0.999912818

p_ni:  0.000087182

Score:  0.84

Data Source:  BioPlex,STRINGDB

FAM124A

Tdark

Novelty:  1.51577847

p_int:  0.999896639

p_ni:  0.000103361

Data Source:  BioPlex

ALOX5

Tclin

Family:  Enzyme

Novelty:  0.00062988

p_int:  0.999879806

p_ni:  0.000120194

Score:  0.189

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (1)

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Downstream (1)

1 – 1 of 1

ITGB2

Tclin

Family:  Other

KEGG Distance:  3

Common Pathways:  1

1: Hippo signaling pathway

Pathways (8)

Reactome (4)

KEGG (3)

WikiPathways (1)

Cell junction organization (R-HSA-446728)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell junction organization	88 targets	R-HSA-446728
Reactome	Cell-Cell communication	121 targets	R-HSA-1500931
Reactome	Cell-cell junction organization	63 targets	R-HSA-421270
Reactome	Tight junction interactions	30 targets	R-HSA-420029

Name	Explore in Pharos	Explore in Source
Cell junction organization	88 targets	R-HSA-446728
Cell-Cell communication	121 targets	R-HSA-1500931
Cell-cell junction organization	63 targets	R-HSA-421270
Tight junction interactions	30 targets	R-HSA-420029

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (18)

Functions (1)

Components (10)

Processes (7)

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GO Term	Evidence	Assigned by
protein domain specific binding	Inferred from Physical Interaction (IPI)	BHF-UCL

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	2	2	3		85.7
reticulocyte count	EFO_0007986	4	1	4		30.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	3		85.7
reticulocyte count	EFO_0007986	4		30.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Membrane
Phosphoprotein
Reference proteome
Repeat
SH3 domain

GWAS Trait Find Similar Targets

No Header	No Header
reticulocyte count
reticulocyte measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
growth/size/body region phenotype
hematopoietic system phenotype
immune system phenotype
integument phenotype
nervous system phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	membrane palmitoylated protein 5	VGNC:10244	452978
Mouse	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)	MGI:1927339	56217
Rat	membrane palmitoylated protein 5	RGD:1308071	314259
Dog	membrane palmitoylated protein 5	VGNC:43346	490740
Horse	membrane palmitoylated protein 5	VGNC:20292	100052602

Species	Name	OMA	EggNOG	Inparanoid
Chimp	membrane palmitoylated protein 5
Mouse	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Rat	membrane palmitoylated protein 5
Dog	membrane palmitoylated protein 5
Horse	membrane palmitoylated protein 5

Publication Statistics

PubMed Score 64.81

PubMed score by year

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PubTator Score 61.62

PubTator score by year

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Related Publications

Text Mined References (42)

GeneRif Annotations (13)

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10

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PMID	Year	Title