MPP5
MAGUK p55 subfamily member 5
Protein Classes
Protein Summary
May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
- ENST00000261681
- ENSP00000261681
- ENSG00000072415
- ENST00000555925
- ENSP00000451488
- PALS1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
kinase perturbation | 0.93 | ||
histone modification site profile | 0.86 | ||
cellular component | 0.79 | ||
microRNA | 0.78 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 60.2 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 305 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 60.2 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 305 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | membrane palmitoylated protein 5 | VGNC:10244 | 452978 | |||||
Mouse | MGI:1927339 | 56217 | ||||||
Rat | RGD:1308071 | 314259 | ||||||
Dog | membrane palmitoylated protein 5 | VGNC:43346 | 490740 | |||||
Horse | membrane palmitoylated protein 5 | VGNC:20292 | 100052602 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | membrane palmitoylated protein 5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | membrane palmitoylated protein 5 | |||||
Horse | membrane palmitoylated protein 5 | |||||
Protein Structure (5 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 5
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (8)
Reactome (4)
KEGG (3)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-cell junction organization | ||||
Reactome | Tight junction interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-cell junction organization | ||||
Tight junction interactions | ||||
Gene Ontology Terms (18)
Functions (1)
Components (10)
Processes (7)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Protein-Protein Interactions (103)
1 – 10 of 103
LIN7C
Novelty: 0.06778878
p_int: 1
Score: 0.943
Data Source: BioPlex,STRINGDB
MPDZ
Novelty: 0.01656439
p_int: 0.999999995
p_ni: 5e-9
Score: 0.978
Data Source: BioPlex,STRINGDB
PATJ
Novelty: 0.01420008
p_int: 0.999999993
p_ni: 7e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
AMOTL2
Novelty: 0.04258164
p_int: 0.999999982
p_ni: 8e-9
p_wrong: 9e-9
Score: 0.605
Data Source: BioPlex,STRINGDB
RPH3A
Family: Epigenetic
Novelty: 0.01321524
p_int: 0.999999901
p_ni: 9.8e-8
p_wrong: 1e-9
Score: 0.169
Data Source: BioPlex,STRINGDB
LIN7B
Novelty: 0.12689192
p_int: 0.999998533
p_ni: 6.5e-8
p_wrong: 0.000001403
Score: 0.964
Data Source: BioPlex,STRINGDB
HOMER3
Novelty: 0.04408998
p_int: 0.999987718
p_ni: 0.000012282
Score: 0.205
Data Source: BioPlex,STRINGDB
AMOTL1
Novelty: 0.03842225
p_int: 0.999912818
p_ni: 0.000087182
Score: 0.84
Data Source: BioPlex,STRINGDB
FAM124A
Novelty: 1.51577847
p_int: 0.999896639
p_ni: 0.000103361
Data Source: BioPlex
ALOX5
Family: Enzyme
Novelty: 0.00062988
p_int: 0.999879806
p_ni: 0.000120194
Score: 0.189
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 60.20
PubMed score by year
PubTator Score 61.62
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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