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Tbio
MPP5
MAGUK p55 subfamily member 5

Protein Summary
Description
May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261681
  • ENSP00000261681
  • ENSG00000072415
  • ENST00000555925
  • ENSP00000451488

Symbol
  • PALS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
kinase perturbation
0.93
histone modification site profile
0.86
cellular component
0.79
microRNA
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.81   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 305   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.81   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 305   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (103)
LIN7C
Tbio
Novelty:  0.06778878
p_int:  1
Score:  0.943
Data Source:  BioPlex,STRINGDB
MPDZ
Tbio
Novelty:  0.01656439
p_int:  0.999999995
p_ni:  5e-9
Score:  0.978
Data Source:  BioPlex,STRINGDB
PATJ
Tbio
Novelty:  0.01420008
p_int:  0.999999993
p_ni:  7e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
AMOTL2
Tbio
Novelty:  0.04258164
p_int:  0.999999982
p_ni:  8e-9
p_wrong:  9e-9
Score:  0.605
Data Source:  BioPlex,STRINGDB
RPH3A
Tbio
Family:  Epigenetic
Novelty:  0.01321524
p_int:  0.999999901
p_ni:  9.8e-8
p_wrong:  1e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
LIN7B
Tbio
Novelty:  0.12689192
p_int:  0.999998533
p_ni:  6.5e-8
p_wrong:  0.000001403
Score:  0.964
Data Source:  BioPlex,STRINGDB
HOMER3
Tbio
Novelty:  0.04408998
p_int:  0.999987718
p_ni:  0.000012282
Score:  0.205
Data Source:  BioPlex,STRINGDB
AMOTL1
Tbio
Novelty:  0.03842225
p_int:  0.999912818
p_ni:  0.000087182
Score:  0.84
Data Source:  BioPlex,STRINGDB
FAM124A
Tdark
Novelty:  1.51577847
p_int:  0.999896639
p_ni:  0.000103361
Data Source:  BioPlex
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
p_int:  0.999879806
p_ni:  0.000120194
Score:  0.189
Data Source:  BioPlex,STRINGDB
Pathways (8)
Cell junction organization (R-HSA-446728)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Tight junction interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Tight junction interactions
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
2
3
85.7
reticulocyte count
4
1
4
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
85.7
reticulocyte count
4
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
membrane palmitoylated protein 5
VGNC:10244
452978
Mouse
MGI:1927339
56217
Rat
RGD:1308071
314259
Dog
membrane palmitoylated protein 5
VGNC:43346
490740
Horse
membrane palmitoylated protein 5
VGNC:20292
100052602
Species
Name
OMA
EggNOG
Inparanoid
Chimp
membrane palmitoylated protein 5
Mouse
Rat
Dog
membrane palmitoylated protein 5
Horse
membrane palmitoylated protein 5
Publication Statistics
PubMed Score 64.81
PubMed score by year
PubTator Score 61.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title