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Tbio
CADM2
Cell adhesion molecule 2

Protein Summary
Description
Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes. This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383699
  • ENSP00000373200
  • ENSG00000175161
  • ENST00000405615
  • ENSP00000384193
  • ENST00000407528
  • ENSP00000384575
  • ENST00000644573
  • ENSP00000496096
  • ENSG00000284780
  • ENST00000644749
  • ENSP00000495354
  • ENST00000647099
  • ENSP00000494084

Symbol
  • IGSF4D
  • NECL3
  • NECL3
  • IGSF4D
  • Necl-3
  • synCAM2
  • SynCAM 2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
microRNA
0.9
trait
0.75
transcription factor
0.74
phenotype
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.16   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.16   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0