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Tbio
PPM1K
Protein phosphatase 1K, mitochondrial

Protein Summary
Description
Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development. This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000608933
  • ENSP00000477341
  • ENSG00000163644

Symbol
  • PP2CM
  • BDP
  • PTMP
  • PP2Cm
  • MSUDMV
  • PP2Ckappa
  • UG0882E07
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor perturbation
0.8
transcription factor binding site profile
0.75
microRNA
0.69
tissue
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.55   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.55   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0