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Tbio
BBS5
Bardet-Biedl syndrome 5 protein

Protein Summary
Description
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly. This gene encodes a protein that has been dir ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295240
  • ENSP00000295240
  • ENSG00000163093
  • ENST00000392663
  • ENSP00000376431
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
cellular component
0.71
gene perturbation
0.62
phenotype
0.58
transcription factor binding site profile
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.17   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.17   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
BBS7
Tbio
Novelty:  0.03611111
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
BBS1
Tbio
Novelty:  0.00939439
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
BBS4
Tbio
Novelty:  0.01825873
p_int:  0.999999955
p_ni:  4.5e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
BBS9
Tbio
Novelty:  0.01879869
p_int:  0.99999985
p_ni:  1.5e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
TTC8
Tbio
Novelty:  0.08520636
p_int:  0.999999463
p_ni:  5.17e-7
p_wrong:  2e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
LZTFL1
Tbio
Novelty:  0.10578428
p_int:  0.999998538
p_ni:  0.000001462
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
NME3
Tbio
Family:  Kinase
Novelty:  0.05947052
p_int:  0.999989837
p_ni:  0.000010143
p_wrong:  1.9e-8
Score:  0.857
Data Source:  BioPlex,STRINGDB
BBS2
Tbio
Novelty:  0.00835161
p_int:  0.9999516
p_ni:  0.0000484
Score:  0.998
Data Source:  BioPlex,STRINGDB
BBS10
Tbio
Novelty:  0.03343798
Score:  0.991
Data Source:  STRINGDB
BBS12
Tbio
Novelty:  0.06131428
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
BBSome-mediated cargo-targeting to cilium (R-HSA-5620922)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BBSome-mediated cargo-targeting to cilium
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
BBSome-mediated cargo-targeting to cilium
Cargo trafficking to the periciliary membrane
Cilium Assembly
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919819
72569
Rat
RGD:1310718
362142
Horse
Bardet-Biedl syndrome 5
100052477
Cow
Bardet-Biedl syndrome 5
528191
Chicken
Bardet-Biedl syndrome 5
CGNC:7481
424165
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
Bardet-Biedl syndrome 5
Cow
Bardet-Biedl syndrome 5
Chicken
Bardet-Biedl syndrome 5
Publication Statistics
PubMed Score 23.17
PubMed score by year
PubTator Score 13.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title