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Tbio
MICALL1
MICAL-like protein 1

Protein Summary
Description
Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215957
  • ENSP00000215957
  • ENSG00000100139

Symbol
  • KIAA1668
  • MIRAB13
  • MIRAB13
  • MICAL-L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
cellular component
0.69
molecular function
0.63
tissue sample
0.61
transcription factor
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.05   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.05   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (41)
1 – 10 of 41
SH3KBP1
Tbio
Family: Enzyme
Novelty: 0.01467085
p_int: 0.999999989
p_ni: 1e-9
p_wrong: 1e-8
Score: 0.176
Data Source: BioPlex,STRINGDB
RAB8B
Tbio
Family: Enzyme
Novelty: 0.10510475
p_int: 0.999999966
p_ni: 3.3e-8
p_wrong: 2e-9
Score: 0.482
Data Source: BioPlex,STRINGDB
ZNF785
Tdark
Family: TF
Novelty: 0.46153846
p_int: 0.998520178
p_ni: 0.001158142
p_wrong: 0.00032168
Data Source: BioPlex
PACSIN3
Tbio
Family: Enzyme
Novelty: 0.17960231
p_int: 0.990137165
p_ni: 0.007129885
p_wrong: 0.00273295
Score: 0.322
Data Source: BioPlex,STRINGDB
EHD1
Tbio
Novelty: 0.00164193
Score: 0.922
Data Source: STRINGDB
RAB35
Tbio
Family: Enzyme
Novelty: 0.0201355
Score: 0.901
Data Source: STRINGDB
ARF6
Tbio
Family: Enzyme
Novelty: 0.00305495
Score: 0.84
Data Source: STRINGDB
EHD3
Tbio
Novelty: 0.01684594
Score: 0.839
Data Source: STRINGDB
RAB13
Tbio
Family: Enzyme
Novelty: 0.03726023
Score: 0.817
Data Source: STRINGDB
RAB8A
Tbio
Family: Enzyme
Novelty: 0.00226947
Score: 0.814
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.05

PubMed score by year
PubTator Score  8.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer