Tbio PLCD3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

Protein Summary

Description

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8N3E9
• Q8TEC1
• Q8TF37
• Q96FL6

Gene Name

• PLCD3

Ensembl ID

• ENST00000619929
• ENSP00000479636
• ENSG00000161714

Symbol

• KIAA1964
• PLC-delta-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
metabolite	0.99
interacting protein	0.78
transcription factor binding site profile	0.7
transcription factor	0.65

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Delta-3

Protein / Hydrolase / Lipase / Phospholipase / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Delta-3

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Delta-3

Protein / Calcium-binding Protein / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Delta-3

DTO Classes

Protein / Enzyme / Hydrolase / Lipase / Phospholipase / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Delta-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.05   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 89   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.05   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0