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Tbio
PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

Protein Classes
Protein Summary
Description
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000619929
  • ENSP00000479636
  • ENSG00000161714

Symbol
  • KIAA1964
  • PLC-delta-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
metabolite
0.99
interacting protein
0.78
transcription factor binding site profile
0.7
transcription factor
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.26   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.26   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
2
3
98.2
1
1
1
67.8
triglyceride measurement
1
1
1
10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
98.2
1
67.8
triglyceride measurement
1
10
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:107451
72469
Rat
RGD:1310903
287745
Dog
phospholipase C delta 3
VGNC:44648
490929
Horse
phospholipase C delta 3
VGNC:21540
100064142
Cow
phospholipase C delta 3
VGNC:32985
513057
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
phospholipase C delta 3
Horse
phospholipase C delta 3
Cow
phospholipase C delta 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N3E9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IP3 and IP4 in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of IP3 and IP4 in the cytosol
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (113)
1 – 10 of 113
GPBP1L1
Tdark
Novelty: 0.69320833
p_int: 0.999998083
p_ni: 0.000001917
Data Source: BioPlex
AHCYL1
Tchem
Family: Enzyme
Novelty: 0.02176432
p_int: 0.999990921
p_ni: 0.000009078
Data Source: BioPlex
PRICKLE3
Tbio
Novelty: 0.26347141
p_int: 0.999986846
p_ni: 0.000013154
Data Source: BioPlex
LRRC46
Tdark
Novelty: 1.159245
p_int: 0.999980336
p_ni: 0.000019664
Score: 0.207
Data Source: BioPlex,STRINGDB
PIP4K2A
Tbio
Family: Kinase
Novelty: 0.01130885
p_int: 0.999484077
p_ni: 0.000515886
p_wrong: 3.8e-8
Score: 0.956
Data Source: BioPlex,STRINGDB
ARIH1
Tbio
Family: Enzyme
Novelty: 0.0258739
p_int: 0.998799825
p_ni: 0.001200173
p_wrong: 2e-9
Data Source: BioPlex
EAF1
Tbio
Novelty: 0.81120425
p_int: 0.998305443
p_ni: 0.001694556
p_wrong: 1e-9
Data Source: BioPlex
GPR156
Tdark
Family: GPCR
Novelty: 0.39183023
p_int: 0.997840071
p_ni: 0.002159927
p_wrong: 1e-9
Data Source: BioPlex
AHCYL2
Tbio
Family: Enzyme
Novelty: 0.08695339
p_int: 0.99445664
p_ni: 0.00554336
Data Source: BioPlex
HDGFL2
Tbio
Family: Epigenetic
Novelty: 0.11846257
p_int: 0.993773652
p_ni: 0.006129286
p_wrong: 0.000097062
Data Source: BioPlex
Publication Statistics
PubMed Score  22.26

PubMed score by year
PubTator Score  11.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer