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Tbio
TMTC2
Transmembrane and TPR repeat-containing protein 2

Protein Summary
Description
The protein encoded by this gene is an integral membrane protein localized to the endoplasmic reticulum (ER). The encoded protein contains many tetratricopeptide repeats, sequences known for being involved in protein-protein interactions. This protein binds both the calcium uptake pump SERCA2B and the carbohydrate-binding chaperone calnexin, and it appears to play a role in calcium homeostasis in the ER. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321196
  • ENSP00000322300
  • ENSG00000179104

Symbol
  • IBDBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
transcription factor perturbation
0.84
transcription factor binding site profile
0.76
trait
0.75
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.06   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.06   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
37.6
gut microbiome measurement
1
1
0
5.8
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
37.6
gut microbiome measurement
0
5.8
26.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transmembrane and tetratricopeptide repeat containing 2
697892
Mouse
MGI:1914057
278279
Rat
RGD:1309848
299762
Dog
transmembrane and tetratricopeptide repeat containing 2
VGNC:47639
482584
Horse
transmembrane and tetratricopeptide repeat containing 2
VGNC:24348
100050838
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transmembrane and tetratricopeptide repeat containing 2
Mouse
Rat
Dog
transmembrane and tetratricopeptide repeat containing 2
Horse
transmembrane and tetratricopeptide repeat containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N394-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (59)
1 – 10 of 59
PCDHB11
Tdark
Novelty:  0.80480462
p_int:  0.999999095
p_ni:  6.07e-7
p_wrong:  2.98e-7
Score:  0.248
Data Source:  BioPlex,STRINGDB
PCDHGB1
Tdark
Novelty:  0.60440805
p_int:  0.999994324
p_ni:  0.000005377
p_wrong:  2.99e-7
Score:  0.23
Data Source:  BioPlex,STRINGDB
CDHR2
Tbio
Novelty:  0.09806551
p_int:  0.999636833
p_ni:  0.000019145
p_wrong:  0.000344023
Data Source:  BioPlex
PLXDC2
Tbio
Novelty:  0.06496695
Score:  0.758
Data Source:  STRINGDB
ZACN
Tchem
Family:  IC
Novelty:  0.21891621
Score:  0.748
Data Source:  STRINGDB
MFSD6
Tbio
Novelty:  0.0161011
Score:  0.658
Data Source:  STRINGDB
ASB7
Tdark
Novelty:  0.21883348
Score:  0.643
Data Source:  STRINGDB
ELP4
Tbio
Novelty:  0.03734233
Score:  0.628
Data Source:  STRINGDB
GABRE
Tclin
Family:  IC
Novelty:  0.03814541
Score:  0.611
Data Source:  STRINGDB
CDC42BPA
Tchem
Family:  Kinase
Novelty:  0.02575412
Score:  0.611
Data Source:  STRINGDB
Publication Statistics
PubMed Score  6.06

PubMed score by year
PubTator Score  4.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer