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Tbio
ARHGAP18
Rho GTPase-activating protein 18

Protein Summary
Description
Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595). ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al., 2009 [PubMed 19065146]).[supplied by OMIM, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368149
  • ENSP00000357131
  • ENSG00000146376

Symbol
  • SENEX
  • MacGAP
  • bA307O14.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
virus perturbation
0.76
transcription factor perturbation
0.74
small molecule perturbation
0.73
histone modification site profile
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.21   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.21   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
1
1
54.1
mean platelet volume
1
1
1
51.9
heel bone mineral density
1
1
1
26.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
54.1
mean platelet volume
1
51.9
heel bone mineral density
1
26.7
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Rho GTPase activating protein 18
711107
Mouse
MGI:1921160
73910
Rat
RGD:1305053
293947
Dog
Rho GTPase activating protein 18
VGNC:38049
476292
Horse
Rho GTPase activating protein 18
VGNC:15461
100073070
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Rho GTPase activating protein 18
Mouse
Rat
Dog
Rho GTPase activating protein 18
Horse
Rho GTPase activating protein 18
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N392-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (35)
1 – 10 of 35
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
p_int: 0.999999954
p_ni: 4.2e-8
p_wrong: 4e-9
Data Source: BioPlex
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.945
Data Source: STRINGDB
RHOC
Tbio
Family: Enzyme
Novelty: 0.00262213
Score: 0.944
Data Source: STRINGDB
RHOQ
Tbio
Family: Enzyme
Novelty: 0.00562425
Score: 0.936
Data Source: STRINGDB
RHOBTB2
Tbio
Novelty: 0.00734789
Score: 0.93
Data Source: STRINGDB
RHOBTB1
Tbio
Novelty: 0.02152609
Score: 0.93
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.93
Data Source: STRINGDB
RHOB
Tbio
Family: Enzyme
Novelty: 0.0019205
Score: 0.926
Data Source: STRINGDB
RHOJ
Tbio
Family: Enzyme
Novelty: 0.01217051
Score: 0.925
Data Source: STRINGDB
RHOU
Tbio
Family: Enzyme
Novelty: 0.01456329
Score: 0.921
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.21

PubMed score by year
PubTator Score  15.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer