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Tbio
LRRC25
Leucine-rich repeat-containing protein 25

Protein Summary
Description
Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy (PubMed:29288164). Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339007
  • ENSP00000340983
  • ENSG00000175489
  • ENST00000595840
  • ENSP00000472290

Symbol
  • MAPA
  • MAPA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.6
tissue sample
0.6
histone modification site profile
0.53
transcription factor
0.47
transcription factor binding site profile
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.74   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 294   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.74   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (21)
SLC25A42
Tbio
Family:  Transporter
Novelty:  0.15737382
Score:  0.659
Data Source:  STRINGDB
B3GALT6
Tbio
Family:  Enzyme
Novelty:  0.05220892
Score:  0.622
Data Source:  STRINGDB
PGPEP1
Tbio
Family:  Enzyme
Novelty:  0.00933029
Score:  0.612
Data Source:  STRINGDB
LRRC31
Tdark
Novelty:  0.46385091
Score:  0.571
Data Source:  STRINGDB
LILRB2
Tbio
Novelty:  0.00545569
Score:  0.552
Data Source:  STRINGDB
SI
Tchem
Family:  Enzyme
Novelty:  0.00048694
Score:  0.539
Data Source:  STRINGDB
SDF4
Tbio
Novelty:  0.00105893
Score:  0.538
Data Source:  STRINGDB
SSBP4
Tdark
Novelty:  0.27365687
Score:  0.531
Data Source:  STRINGDB
RAI14
Tbio
Novelty:  0.06291577
Score:  0.507
Data Source:  STRINGDB
CD34
Tbio
Novelty:  0.00005468
Score:  0.499
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Vitamin D Receptor Pathway
WikiPathways
Vitamin D Receptor Pathway
WikiPathways
Vitamin D Receptor Pathway
WikiPathways
Vitamin D Receptor Pathway
WikiPathways
Small cell lung cancer
Name
Explore in Pharos
Explore in Source
Vitamin D Receptor Pathway
Vitamin D Receptor Pathway
Vitamin D Receptor Pathway
Vitamin D Receptor Pathway
Small cell lung cancer
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (54)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
growth differentiation factor 15 measurement
4
6
7
99.3
neutrophil percentage of leukocytes
2
2
2
84.2
neutrophil count
3
2
3
83.3
red blood cell density measurement
1
1
1
81.2
granulocyte percentage of myeloid white cells
1
2
2
80.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
growth differentiation factor 15 measurement
7
99.3
neutrophil percentage of leukocytes
2
84.2
neutrophil count
3
83.3
red blood cell density measurement
1
81.2
granulocyte percentage of myeloid white cells
2
80.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 25
VGNC:2320
749015
Macaque
leucine rich repeat containing 25
719475
Mouse
MGI:2445284
211228
Rat
RGD:1564818
498605
Dog
leucine rich repeat containing 25
VGNC:42791
609889
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 25
Macaque
leucine rich repeat containing 25
Mouse
Rat
Dog
leucine rich repeat containing 25
Publication Statistics
PubMed Score 54.74
PubMed score by year
PubTator Score 59.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title