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Tbio
KDM8
Bifunctional peptidase and arginyl-hydroxylase JMJD5

Protein Summary
Description
Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961, PubMed:29459673, PubMed:28982940). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961, PubMed:29459673). Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage (PubMed:28982940). Additionnally, acts as a Fe(2+) and 2-oxoglutarate-dependent oxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established (PubMed:29563586). Regulates mitosis through d ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286096
  • ENSP00000286096
  • ENSG00000155666
  • ENST00000441782
  • ENSP00000398410
  • ENST00000568965
  • ENSP00000456901

Symbol
  • JMJD5
  • JMJD5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.78
tissue sample
0.71
histone modification site profile
0.7
cell type or tissue
0.69
biological process
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.92   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.92   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
1
2
70.5
1
1
0
1
46.9
IGF-1 measurement
1
1
1
44.2
Inhalant adrenergic use measurement
1
1
1
17.8
1
1
0
7.7
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
70.5
0
1
46.9
IGF-1 measurement
1
44.2
Inhalant adrenergic use measurement
1
17.8
0
7.7
15.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 8
VGNC:8985
454003
Macaque
lysine demethylase 8
703323
Mouse
MGI:1924285
77035
Rat
RGD:1304823
308976
Dog
lysine demethylase 8
VGNC:42330
608058
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 8
Macaque
lysine demethylase 8
Mouse
Rat
Dog
lysine demethylase 8
Protein Structure (17 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8N371-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (12)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (57)
1 – 10 of 57
RCCD1
Tbio
Novelty:  0.07481641
p_int:  0.999999996
p_wrong:  3e-9
Score:  0.959
Data Source:  BioPlex,STRINGDB
CSTL1
Tbio
Novelty:  0.13370814
p_int:  0.999999993
p_ni:  6e-9
Data Source:  BioPlex
FCER1A
Tbio
Novelty:  0.00362182
p_int:  0.999999655
p_ni:  3.45e-7
Data Source:  BioPlex
CD70
Tbio
Novelty:  0.00420393
p_int:  0.999997964
p_ni:  0.000001363
p_wrong:  6.73e-7
Data Source:  BioPlex
CCDC130
Tdark
Novelty:  0.34042834
p_int:  0.999985701
p_ni:  0.000014181
p_wrong:  1.18e-7
Score:  0.823
Data Source:  BioPlex,STRINGDB
TPST2
Tbio
Family:  Enzyme
Novelty:  0.02551048
p_int:  0.999591523
p_ni:  0.00039994
p_wrong:  0.000008537
Data Source:  BioPlex
UNC5CL
Tbio
Novelty:  0.11511991
p_int:  0.995051101
p_ni:  0.000579252
p_wrong:  0.004369648
Score:  0.253
Data Source:  BioPlex,STRINGDB
RPS6
Tbio
Novelty:  0.00122241
Score:  0.83
Data Source:  STRINGDB
RIOX1
Tbio
Family:  Epigenetic
Novelty:  0.06360414
Score:  0.798
Data Source:  STRINGDB
PKM
Tchem
Family:  Kinase
Novelty:  0.00076567
Score:  0.758
Data Source:  STRINGDB
Publication Statistics
PubMed Score  35.92

PubMed score by year
PubTator Score  17.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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