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Tbio
SLC35F6
Solute carrier family 35 member F6

Protein Summary
Description
Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344420
  • ENSP00000345528
  • ENSG00000213699

Symbol
  • C2orf18
  • ANT2BP
  • TANGO9
  • C2orf18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
tissue sample
0.7
small molecule perturbation
0.62
cell line
0.61
tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.23   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.23   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
ORAI1
Tchem
Family:  IC
Novelty:  0.00179685
p_int:  0.970875582
p_ni:  0.028962947
p_wrong:  0.000161471
Data Source:  BioPlex
KLK15
Tbio
Family:  Enzyme
Novelty:  0.00083978
p_int:  0.855197772
p_ni:  0.144786921
p_wrong:  0.000015307
Data Source:  BioPlex
MGARP
Tbio
Novelty:  0.02883753
p_int:  0.767938045
p_ni:  0.157389415
p_wrong:  0.07467254
Data Source:  BioPlex
OTUD4
Tbio
Novelty:  0.17121119
Score:  0.708
Data Source:  STRINGDB
NUS1
Tbio
Family:  Enzyme
Novelty:  0.02022029
Score:  0.703
Data Source:  STRINGDB
LMBRD1
Tbio
Novelty:  0.02503332
Score:  0.681
Data Source:  STRINGDB
NUDT3
Tbio
Family:  Enzyme
Novelty:  0.06052313
Score:  0.656
Data Source:  STRINGDB
SLC25A5
Tchem
Family:  Transporter
Novelty:  0.00749909
Score:  0.645
Data Source:  STRINGDB
UAP1L1
Tdark
Family:  Enzyme
Novelty:  0.36065169
Score:  0.628
Data Source:  STRINGDB
PITPNB
Tbio
Novelty:  0.03432693
Score:  0.628
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
5
5
8
89.9
triglyceride measurement
2
3
3
89.4
2
5
5
88.6
C-reactive protein measurement
2
3
4
84
Calcium channel blocker use measurement
1
1
1
80
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
8
89.9
triglyceride measurement
3
89.4
5
88.6
C-reactive protein measurement
4
84
Calcium channel blocker use measurement
1
80
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 35 member F6
VGNC:10763
459085
Mouse
MGI:1922169
74919
Rat
RGD:1309228
298851
Dog
solute carrier family 35 member F6
VGNC:46380
483003
Horse
solute carrier family 35 member F6
VGNC:23177
100071319
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 35 member F6
Mouse
Rat
Dog
solute carrier family 35 member F6
Horse
solute carrier family 35 member F6
Publication Statistics
PubMed Score 1.23
PubMed score by year
PubTator Score 1.33
PubTator score by year
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Related Publications
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PMID
Year
Title