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Tbio
MIER2
Mesoderm induction early response protein 2

Protein Summary
Description
Transcriptional repressor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264819
  • ENSP00000264819
  • ENSG00000105556

Symbol
  • KIAA1193
  • Mi-er2
  • KIAA1193
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
disease perturbation
0.74
transcription factor perturbation
0.68
cell line
0.67
cell type or tissue
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.22   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.22   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
CDYL
Tchem
Family:  Epigenetic
Novelty:  0.03367841
p_int:  1
Score:  0.613
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  1
Score:  0.458
Data Source:  BioPlex,STRINGDB
CYBRD1
Tbio
Family:  Enzyme
Novelty:  0.01128708
p_int:  0.999996059
p_ni:  0.000003921
p_wrong:  2e-8
Score:  0.813
Data Source:  BioPlex,STRINGDB
C16orf87
Tdark
Novelty:  5.71664261
p_int:  0.999969271
p_ni:  0.000007767
p_wrong:  0.000022962
Data Source:  BioPlex
L3MBTL2
Tbio
Family:  Epigenetic
Novelty:  0.11193867
p_int:  0.999963511
p_ni:  0.000036488
Score:  0.637
Data Source:  BioPlex,STRINGDB
E2F6
Tbio
Family:  TF
Novelty:  0.00753541
p_int:  0.999921367
p_ni:  0.000077905
p_wrong:  7.28e-7
Score:  0.761
Data Source:  BioPlex,STRINGDB
EHMT2
Tchem
Family:  Epigenetic
Novelty:  0.00262578
p_int:  0.999887522
p_ni:  0.000112477
p_wrong:  1e-9
Score:  0.251
Data Source:  BioPlex,STRINGDB
TFDP1
Tbio
Family:  TF
Novelty:  0.02026858
p_int:  0.999837416
p_ni:  0.000148654
p_wrong:  0.00001393
Score:  0.737
Data Source:  BioPlex,STRINGDB
MGA
Tbio
Family:  TF
Novelty:  0.08965274
p_int:  0.999820734
p_ni:  0.000179266
Score:  0.622
Data Source:  BioPlex,STRINGDB
EHMT1
Tchem
Family:  Epigenetic
Novelty:  0.00821799
p_int:  0.999729411
p_ni:  0.000270589
Score:  0.326
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
56.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
56.2
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MIER family member 2
VGNC:7489
455527
Macaque
MIER family member 2
701450
Mouse
MGI:1917677
70427
Rat
RGD:1307278
362841
Dog
MIER family member 2
VGNC:43230
612437
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MIER family member 2
Macaque
MIER family member 2
Mouse
Rat
Dog
MIER family member 2
Publication Statistics
PubMed Score 1.22
PubMed score by year
PubTator Score 1.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title