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Tbio
MT1M
Metallothionein-1M

Protein Summary
Description
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. This gene encodes a member of the metallothionein superfamily, type 1 family. Metallothioneins have a high content of cysteine residues that bind various heavy metals. These genes are transcriptionally regulated by both heavy metals and glucocorticoids. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379818
  • ENSP00000369146
  • ENSG00000205364

Symbol
  • MT1K
  • MT1
  • MT1K
  • MT-1M
  • MT-IM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
small molecule perturbation
0.63
disease
0.51
PubMedID
0.5
cell type or tissue
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.78   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.78   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (55)
1 – 10 of 55
MT1G
Tbio
Novelty:  0.02173544
p_int:  0.999994023
p_wrong:  0.000005977
Score:  0.552
Data Source:  BioPlex,STRINGDB
UBA52
Tbio
Novelty:  0.01637744
p_int:  0.99997169
p_ni:  0.00002831
Data Source:  BioPlex
TPPP2
Tdark
Novelty:  0.22245887
p_int:  0.995933352
p_ni:  0.004066648
Data Source:  BioPlex
MT1E
Tbio
Novelty:  0.01749426
p_int:  0.988449263
p_ni:  1e-9
p_wrong:  0.011550737
Score:  0.7
Data Source:  BioPlex,STRINGDB
PGP
Tbio
Family:  Enzyme
Novelty:  0.0225528
p_int:  0.955579224
p_ni:  0.044420769
p_wrong:  8e-9
Data Source:  BioPlex
NEFH
Tbio
Novelty:  0.0013027
p_int:  0.909363717
p_ni:  0.088953324
p_wrong:  0.001682959
Data Source:  BioPlex
MTF1
Tbio
Family:  TF
Novelty:  0.01350821
Score:  0.901
Data Source:  STRINGDB
CAT
Tbio
Family:  Enzyme
Novelty:  0.00181888
Score:  0.708
Data Source:  STRINGDB
SLC30A1
Tbio
Family:  Transporter
Novelty:  0.00528427
Score:  0.706
Data Source:  STRINGDB
HPGDS
Tchem
Family:  Enzyme
Novelty:  0.00019629
Score:  0.63
Data Source:  STRINGDB
Pathways (5)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Metallothioneins bind metals
Reactome
Response to metal ions
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Metallothioneins bind metals
Response to metal ions
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
13
14
98.3
apolipoprotein A 1 measurement
2
9
9
96.9
sleep duration
2
3
3
63.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
14
98.3
apolipoprotein A 1 measurement
9
96.9
sleep duration
3
63.9
Find similar targets by:
Publication Statistics
PubMed Score 39.78
PubMed score by year
PubTator Score 12.74
PubTator score by year