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Tbio
GPD1L
Glycerol-3-phosphate dehydrogenase 1-like protein

Protein Summary
Description
Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. The protein encoded by this gene catalyzes the conversion of sn-glycerol 3-phosphate to glycerone phosphate. The encoded protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Defects in this gene are a cause of Brugada syndrome type 2 (BRS2) as well as sudden infant death syndrome (SIDS). [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282541
  • ENSP00000282541
  • ENSG00000152642

Symbol
  • KIAA0089
  • GPD1-L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological process
0.91
transcription factor perturbation
0.8
molecular function
0.79
tissue sample
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.4   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.4   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PA
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PA
Gene Ontology Terms (24)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (161)
1 – 10 of 161
GPD1
Tbio
Family: Enzyme
Novelty: 0.00846037
p_int: 0.999699366
p_ni: 0.000300634
Score: 0.87
Data Source: BioPlex,STRINGDB
FAS
Tbio
Novelty: 0.00049744
p_int: 0.996436452
p_ni: 0.003563548
Data Source: BioPlex
SLC3A2
Tbio
Family: Transporter
Novelty: 0.00258645
p_int: 0.995064068
p_ni: 0.004935931
Data Source: BioPlex
ISLR
Tbio
Novelty: 0.10472842
p_int: 0.987459069
p_ni: 0.012540931
Data Source: BioPlex
LAMP2
Tbio
Novelty: 0.00223951
p_int: 0.978115344
p_ni: 0.021884656
Score: 0.258
Data Source: BioPlex,STRINGDB
TGOLN2
Tbio
Novelty: 0.00791111
p_int: 0.976279938
p_ni: 0.023720062
Data Source: BioPlex
CST8
Tbio
Novelty: 0.00274495
p_int: 0.966843016
p_ni: 0.033156984
Data Source: BioPlex
MICB
Tbio
Novelty: 0.00776922
p_int: 0.920389667
p_ni: 0.079610333
Data Source: BioPlex
FAM174A
Tdark
Novelty: 0.44599913
p_int: 0.853482076
p_ni: 0.146517924
Data Source: BioPlex
GLMP
Tdark
Novelty: 0.08368201
p_int: 0.849212964
p_ni: 0.150787036
Data Source: BioPlex
Publication Statistics
PubMed Score  50.40

PubMed score by year
PubTator Score  12.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer