Tbio MUC20 Mucin-20

Protein Summary

Description

May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression. This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• Q8N307
• Q6UX97
• Q76I83
• Q76I85
• Q86ST8
• Q8NBY6
• Q96KA1
• Q9P2I8
• MUC-20

Gene Name

• MUC20

Ensembl ID

• ENST00000445522
• ENSP00000405629
• ENSG00000176945
• ENST00000447234
• ENSP00000414350
• ENST00000610415
• ENSP00000479947
• ENSG00000278114
• ENST00000615394
• ENSP00000483878
• ENSG00000276583
• ENST00000620530
• ENSP00000479182
• ENSG00000275501
• ENST00000625274
• ENSP00000485837
• ENST00000627739
• ENSP00000485855
• ENST00000630334
• ENSP00000485921

Symbol

• KIAA1359
• MUC-20

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.8
biological process	0.68
cellular component	0.61
tissue sample	0.61
kinase perturbation	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.48   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 185   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.48   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0