Tbio AGGF1 Angiogenic factor with G patch and FHA domains 1

Protein Summary

Description

Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. This gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16.[provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• Q8N302
• O00581
• Q53YS3
• Q9BU84
• Q9NW66

Gene Name

• AGGF1

Ensembl ID

• ENST00000312916
• ENSP00000316109
• ENSG00000164252
• ENST00000506806
• ENSP00000424733

Symbol

• GPATC7
• GPATCH7
• VG5Q
• VG5Q
• GPATC7
• GPATCH7
• HSU84971
• HUS84971

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
histone modification site profile	0.85
transcription factor perturbation	0.8
PubMedID	0.77
virus perturbation	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.42   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 239   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.42   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0