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Tbio
CENPS
Centromere protein S

Protein Summary
Description
DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM (PubMed:20347428, PubMed:20347429). In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428). In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to for ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309048
  • ENSP00000308583
  • ENSG00000175279

Symbol
  • APITD1
  • FAAP16
  • MHF1
  • MHF1
  • CENPS
  • APITD1
  • CENP-S
  • FAAP16
  • APITD1-CORT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.56   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.56   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8N2Z9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (196)
1 – 10 of 196
FANCF
Tchem
Novelty: 0.01745498
Score: 0.999
Data Source: STRINGDB
FAAP24
Tbio
Novelty: 0.08081633
Score: 0.999
Data Source: Reactome,STRINGDB
FANCM
Tbio
Novelty: 0.01122278
Score: 0.999
Data Source: Reactome,STRINGDB
CENPX
Tbio
Novelty: 0.08344454
Score: 0.999
Data Source: Reactome,STRINGDB
BLM
Tchem
Novelty: 0.00662454
Score: 0.999
Data Source: STRINGDB
FANCE
Tbio
Novelty: 0.04484113
Score: 0.999
Data Source: STRINGDB
TOP3A
Tbio
Family: Enzyme
Novelty: 0.0055546
Score: 0.999
Data Source: STRINGDB
FANCG
Tbio
Novelty: 0.00908902
Score: 0.999
Data Source: STRINGDB
RMI1
Tbio
Novelty: 0.01222442
Score: 0.999
Data Source: STRINGDB
RPA1
Tchem
Novelty: 0.00212665
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  86.56

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer