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Tbio
RUSC2
Iporin

Protein Summary
Description
This gene encodes a RUN and SH3 domain containing protein that interacts with Rab1b and Rab1-binding protein GM130. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361226
  • ENSP00000355177
  • ENSG00000198853
  • ENST00000455600
  • ENSP00000393922

Symbol
  • KIAA0375
  • MRT61
  • Iporin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor
0.87
transcription factor binding site profile
0.87
small molecule perturbation
0.71
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.72   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.72   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
RAB1B
Tbio
Family:  Enzyme
Novelty:  0.02156819
Score:  0.918
Data Source:  STRINGDB
GOLGA2
Tbio
Novelty:  0.00544771
Score:  0.794
Data Source:  STRINGDB
TESK1
Tchem
Family:  Kinase
Novelty:  0.06769478
Score:  0.744
Data Source:  STRINGDB
ABCG4
Tbio
Family:  Transporter
Novelty:  0.02628545
Score:  0.715
Data Source:  STRINGDB
LTB4R2
Tchem
Family:  GPCR
Novelty:  0.01094048
Score:  0.682
Data Source:  STRINGDB
GIT1
Tbio
Family:  Enzyme
Novelty:  0.01022741
Score:  0.679
Data Source:  STRINGDB
CIDEB
Tbio
Novelty:  0.01514215
Score:  0.675
Data Source:  STRINGDB
ACAP2
Tbio
Novelty:  0.06711155
Score:  0.662
Data Source:  STRINGDB
ATXN7L2
Tdark
Novelty:  2.89202293
Score:  0.65
Data Source:  STRINGDB
MAPK15
Tchem
Family:  Kinase
Novelty:  0.02414054
Score:  0.634
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
49.5
mean platelet volume
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
49.5
mean platelet volume
1
39.6
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RUN and SH3 domain containing 2
VGNC:4855
465072
Mouse
MGI:2140371
100213
Rat
RGD:1592688
684259
Dog
RUN and SH3 domain containing 2
VGNC:45810
481593
Horse
RUN and SH3 domain containing 2
VGNC:22631
100055624
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RUN and SH3 domain containing 2
Mouse
Rat
Dog
RUN and SH3 domain containing 2
Horse
RUN and SH3 domain containing 2
Publication Statistics
PubMed Score 6.72
PubMed score by year
PubTator Score 4.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title