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Tbio
PIAS4
E3 SUMO-protein ligase PIAS4

Protein Summary
Description
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262971
  • ENSP00000262971
  • ENSG00000105229

Symbol
  • PIASG
  • PIASY
  • Piasg
  • ZMIZ6
  • PIAS-gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.96
biological process
0.84
molecular function
0.76
transcription factor
0.73
transcription factor binding site profile
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.05   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 336   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.05   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
83.3
high density lipoprotein cholesterol measurement
1
1
1
41.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
83.3
high density lipoprotein cholesterol measurement
1
41.5
Pathways (160)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double Strand Break Response
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
DNA Double Strand Break Response
DNA Double-Strand Break Repair
DNA Repair
Gene Ontology Terms (24)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (206)
1 – 10 of 206
CA10
Tbio
Family: Enzyme
Novelty: 0.01053152
p_int: 0.999999223
p_ni: 2.1e-8
p_wrong: 7.56e-7
Score: 0.309
Data Source: BioPlex,STRINGDB
RAD54L2
Tdark
Family: Enzyme
Novelty: 0.26668341
p_int: 0.999997739
p_ni: 0.000002244
p_wrong: 1.7e-8
Score: 0.196
Data Source: BioPlex,STRINGDB
ZCCHC12
Tbio
Novelty: 0.16283891
p_int: 0.999972746
p_ni: 1.24e-7
p_wrong: 0.00002713
Data Source: BioPlex
RREB1
Tbio
Family: TF
Novelty: 0.01394277
p_int: 0.999854413
p_ni: 0.000129204
p_wrong: 0.000016383
Data Source: BioPlex
ZMYM1
Tdark
Novelty: 0.3860445
p_int: 0.999744979
p_ni: 0.000255021
Data Source: BioPlex
SLX4
Tbio
Family: Enzyme
Novelty: 0.01677273
p_int: 0.999276664
p_ni: 0.000022635
p_wrong: 0.000700701
Score: 0.165
Data Source: BioPlex,STRINGDB
SIMC1
Tbio
Novelty: 0.39770049
p_int: 0.999237966
p_ni: 0.000762034
Data Source: BioPlex
SETX
Tbio
Family: Enzyme
Novelty: 0.00474094
p_int: 0.999089217
p_ni: 0.000910783
Data Source: BioPlex
ATF7IP
Tbio
Novelty: 0.04269323
p_int: 0.99897908
p_ni: 0.001019497
p_wrong: 0.000001423
Data Source: BioPlex
KDM5C
Tchem
Family: TF; Epigenetic
Novelty: 0.00701855
p_int: 0.997920697
p_ni: 0.002079198
p_wrong: 1.05e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  72.05

PubMed score by year
PubTator Score  59.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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