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Tbio
LTBP4
Latent-transforming growth factor beta-binding protein 4

Protein Classes
Protein Summary
Description
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308370
  • ENSP00000311905
  • ENSG00000090006
  • ENST00000396819
  • ENSP00000380031

Symbol
  • ARCL1C
  • LTBP-4
  • LTBP4L
  • LTBP4S
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
viral protein
0.98
protein domain
0.97
transcription factor perturbation
0.96
molecular function
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.72   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.72   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
2
2
2
90.8
appendicular lean mass
1
1
1
47.9
eosinophil count
1
1
1
41.8
peak expiratory flow
1
1
1
29.8
hematocrit
1
1
1
28.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
2
90.8
appendicular lean mass
1
47.9
eosinophil count
1
41.8
peak expiratory flow
1
29.8
hematocrit
1
28.3
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1321395
108075
Rat
RGD:1307033
292734
Dog
latent transforming growth factor beta binding protein 4
VGNC:42859
444849
Horse
latent transforming growth factor beta binding protein 4
VGNC:51048
100064750
Opossum
latent transforming growth factor beta binding protein 4 [Source:HGNC Symbol;Acc:HGNC:6717]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
latent transforming growth factor beta binding protein 4
Horse
latent transforming growth factor beta binding protein 4
Opossum
latent transforming growth factor beta binding protein 4 [Source:HGNC Symbol;Acc:HGNC:6717]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N2S1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Molecules associated with elastic fibres
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Molecules associated with elastic fibres
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (38)
1 – 10 of 38
HRG
Tbio
Novelty: 0.0027048
p_int: 0.999896217
p_ni: 0.000103783
Data Source: BioPlex
ZNF408
Tbio
Family: TF
Novelty: 0.10649477
p_int: 0.999889067
p_ni: 0.000110933
Data Source: BioPlex
DNAJC10
Tbio
Novelty: 0.02258366
p_int: 0.996742458
p_ni: 0.003257542
Data Source: BioPlex
ZNF331
Tbio
Family: TF
Novelty: 0.05976217
p_int: 0.99599301
p_ni: 0.00400699
Data Source: BioPlex
ZNF669
Tdark
Family: TF
Novelty: 2.09725685
p_int: 0.994926196
p_ni: 0.005073788
p_wrong: 1.6e-8
Data Source: BioPlex
ZFP41
Tdark
Family: TF
Novelty: 3.33093006
p_int: 0.993035815
p_ni: 0.006964185
Data Source: BioPlex
ZNF169
Tdark
Family: TF
Novelty: 1.09432767
p_int: 0.986001068
p_ni: 0.013998926
p_wrong: 6e-9
Data Source: BioPlex
ZNF707
Tdark
Family: TF
Novelty: 1.42194815
p_int: 0.975615658
p_ni: 0.024384342
Score: 0.212
Data Source: BioPlex,STRINGDB
NELL1
Tbio
Family: Enzyme
Novelty: 0.01325888
p_int: 0.955471909
p_ni: 0.044528088
p_wrong: 3e-9
Data Source: BioPlex
ZNF263
Tbio
Family: TF
Novelty: 0.098799
p_int: 0.942693964
p_ni: 0.057305887
p_wrong: 1.49e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  56.72

PubMed score by year
PubTator Score  28.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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