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Tbio
NLGN1
Neuroligin-1

Protein Summary
Description
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep. This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361589
  • ENSP00000354541
  • ENSG00000169760
  • ENST00000457714
  • ENSP00000392500

Symbol
  • KIAA1070
  • NL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
kinase perturbation
0.84
cellular component
0.75
protein domain
0.73
cell type or tissue
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.8   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.8   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 60
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (179)
1 – 10 of 179
NLGN3
Tbio
Family:  Enzyme
Novelty:  0.00819625
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.938
Data Source:  BioPlex,STRINGDB
ADCY9
Tbio
Family:  Enzyme
Novelty:  0.00744116
p_int:  0.999812424
p_ni:  0.000187573
p_wrong:  3e-9
Data Source:  BioPlex
TNFSF18
Tbio
Novelty:  0.01423949
p_int:  0.999622987
p_ni:  0.000375928
p_wrong:  0.000001085
Data Source:  BioPlex
EDDM3A
Tdark
Novelty:  0.05607223
p_int:  0.985368131
p_ni:  0.014626155
p_wrong:  0.000005714
Data Source:  BioPlex
FAM19A5
Tdark
Novelty:  0.07792418
p_int:  0.962515122
p_ni:  0.010361728
p_wrong:  0.027123151
Data Source:  BioPlex
B3GAT3
Tbio
Family:  Enzyme
Novelty:  0.0289834
p_int:  0.951261497
p_ni:  0.001656523
p_wrong:  0.04708198
Score:  0.206
Data Source:  BioPlex,STRINGDB
NRXN1
Tbio
Novelty:  0.00454659
Score:  0.998
Data Source:  STRINGDB
NRXN3
Tbio
Novelty:  0.00999084
Score:  0.998
Data Source:  STRINGDB
NRXN2
Tbio
Novelty:  0.01252742
Score:  0.998
Data Source:  STRINGDB
NRXN2
Tbio
Novelty:  0.01252742
Score:  0.998
Data Source:  STRINGDB
Pathways (8)
Neurexins and neuroligins (R-HSA-6794361)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Gene Ontology Terms (80)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Non-traceable Author Statement (NAS)
ARUK-UCL
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
3
3
86.1
2
3
3
63.2
insomnia measurement
1
2
0
1
62.6
smoking status measurement
2
3
4
60.9
body height
1
1
1
59.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
86.1
3
63.2
insomnia measurement
0
1
62.6
smoking status measurement
4
60.9
body height
1
59.9
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuroligin 1
VGNC:13008
470999
Macaque
neuroligin 1
693541
Mouse
MGI:2179435
192167
Rat
RGD:621117
116647
Dog
neuroligin 1 [Source:HGNC Symbol;Acc:HGNC:14291]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuroligin 1
Macaque
neuroligin 1
Mouse
Rat
Dog
neuroligin 1 [Source:HGNC Symbol;Acc:HGNC:14291]
Publication Statistics
PubMed Score 127.80
PubMed score by year
PubTator Score 115.09
PubTator score by year