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Tdark
TMEM86A
Lysoplasmalogenase-like protein TMEM86A

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280734
  • ENSP00000280734
  • ENSG00000151117
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
microRNA
0.71
tissue sample
0.67
tissue
0.57
small molecule perturbation
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.65   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 17   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.65   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
4
5
92.6
total cholesterol measurement
3
3
6
73.8
Myopia
1
1
0
1.1
55.2
body height
1
1
1
44.2
refractive error measurement
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
5
92.6
total cholesterol measurement
6
73.8
Myopia
0
1.1
55.2
body height
1
44.2
refractive error measurement
1
38.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 86A
VGNC:966
466461
Mouse
MGI:1915143
67893
Rat
RGD:1305749
308602
Dog
transmembrane protein 86A
VGNC:47608
485407
Horse
transmembrane protein 86A
VGNC:24318
100057256
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 86A
Mouse
Rat
Dog
transmembrane protein 86A
Horse
transmembrane protein 86A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N2M4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (48)
1 – 10 of 48
LRRC3C
Tdark
Novelty:  0.8248881
Score:  0.775
Data Source:  STRINGDB
NXPH2
Tdark
Novelty:  0.65790631
Score:  0.729
Data Source:  STRINGDB
TSPAN2
Tbio
Novelty:  0.03842973
Score:  0.722
Data Source:  STRINGDB
ASNA1
Tbio
Family:  Enzyme
Novelty:  0.01260233
Score:  0.709
Data Source:  STRINGDB
CKS1B
Tbio
Family:  Enzyme
Novelty:  0.00766779
Score:  0.684
Data Source:  STRINGDB
VIPR1
Tchem
Family:  GPCR
Novelty:  0.0016529
Score:  0.681
Data Source:  STRINGDB
ADAMTS3
Tbio
Family:  Enzyme
Novelty:  0.00578975
Score:  0.666
Data Source:  STRINGDB
DLST
Tbio
Family:  Enzyme
Novelty:  0.01516932
Score:  0.66
Data Source:  STRINGDB
LAPTM4B
Tbio
Novelty:  0.01162533
Score:  0.656
Data Source:  STRINGDB
PTGS1
Tclin
Family:  Enzyme
Novelty:  0.00043214
Score:  0.655
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.65

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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