Tbio UBE2J2 Ubiquitin-conjugating enzyme E2 J2

Protein Summary

Description

Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8N2K1
• A8MYC7
• Q504T9
• Q96N26
• Q96T84

Gene Name

• UBE2J2

Ensembl ID

• ENST00000349431
• ENSP00000305826
• ENSG00000160087
• ENST00000360466
• ENSP00000353653
• ENST00000400930
• ENSP00000383719

Symbol

• NCUBE2
• NCUBE2
• NCUBE-2
• PRO2121

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
disease perturbation	0.79
virus perturbation	0.59
transcription factor binding site profile	0.57
histone modification site profile	0.56

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Ubiquitin-conjugating Enzyme E2 J2

Protein / ... / Ubiquitin-protein Ligase / Ubiquitin-conjugating Enzyme E2 J2

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / Ubiquitin-conjugating Enzyme E2 J2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.74   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 132   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.74   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0