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Tchem
ABHD12
Monoacylglycerol lipase ABHD12

Protein Summary
Description
Lysophosphatidylserine (LPS) lipase that plays a key role in the central nervous system. Represents a major LPS lipase in the brain (By similarity). May also have a 2-arachidonoylglycerol (2-AG) hydrolase activity and act as a regulator of endocannabinoid signaling pathways. This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339157
  • ENSP00000341408
  • ENSG00000100997
  • ENST00000376542
  • ENSP00000365725

Symbol
  • C20orf22
  • PHARC
  • ABHD12A
  • BEM46L2
  • C20orf22
  • dJ965G21.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.71
histone modification site profile
0.67
transcription factor
0.67
transcription factor binding site profile
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.93   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.93   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
orlistat
chemical structure image
Active Ligands (1)
1 – 1 of 1
DO264
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
2
66.9
hematocrit
2
2
2
63
alkaline phosphatase measurement
1
1
0
1.5
44.1
forced expiratory volume
1
1
1
40.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
66.9
hematocrit
2
63
alkaline phosphatase measurement
0
1.5
44.1
forced expiratory volume
1
40.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
abhydrolase domain containing 12
VGNC:6027
744997
Macaque
abhydrolase domain containing 12
705915
Mouse
MGI:1923442
76192
Rat
RGD:1562570
499913
Dog
abhydrolase domain containing 12
VGNC:37458
477004
Species
Name
OMA
EggNOG
Inparanoid
Chimp
abhydrolase domain containing 12
Macaque
abhydrolase domain containing 12
Mouse
Rat
Dog
abhydrolase domain containing 12
Pathways (9)
Arachidonate production from DAG (R-HSA-426048)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonate production from DAG
Reactome
Effects of PIP2 hydrolysis
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Arachidonate production from DAG
Effects of PIP2 hydrolysis
G alpha (q) signalling events
GPCR downstream signalling
Hemostasis
Protein-Protein Interactions (68)
1 – 10 of 68
SLC39A12
Tbio
Family: Transporter
Novelty: 0.09127395
p_int: 0.985605042
p_ni: 0.014394958
Data Source: BioPlex
DPP9
Tchem
Family: Enzyme
Novelty: 0.00976924
p_int: 0.94870552
p_ni: 0.051294463
p_wrong: 1.7e-8
Score: 0.258
Data Source: BioPlex,STRINGDB
PLAC9
Tdark
Novelty: 0.23764669
p_int: 0.923869258
p_ni: 0.076130742
Data Source: BioPlex
PEX19
Tbio
Novelty: 0.00605342
p_int: 0.920802981
p_ni: 0.079197019
Score: 0.186
Data Source: BioPlex,STRINGDB
CPVL
Tbio
Family: Enzyme
Novelty: 0.0616903
p_int: 0.85786761
p_ni: 0.14213239
Score: 0.371
Data Source: BioPlex,STRINGDB
SLC39A4
Tbio
Family: Transporter
Novelty: 0.00742159
p_int: 0.851615649
p_ni: 0.148384351
Data Source: BioPlex
ABHD6
Tchem
Family: Enzyme
Novelty: 0.019314
Score: 0.964
Data Source: STRINGDB
MGLL
Tchem
Family: Enzyme
Novelty: 0.00196912
Score: 0.832
Data Source: STRINGDB
FAAH
Tchem
Family: Enzyme
Novelty: 0.00162361
Score: 0.82
Data Source: STRINGDB
GDE1
Tbio
Family: Enzyme
Novelty: 0.05854843
Score: 0.788
Data Source: STRINGDB
Publication Statistics
PubMed Score  34.93

PubMed score by year
PubTator Score  14.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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