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Tbio
SYS1
Protein SYS1 homolog

Protein Summary
Description
Involved in protein trafficking. May serve as a receptor for ARFRP1. SYS1 forms a complex with ADP-ribosylation factor-related protein ARFRP1 (MIM 604699) and targets ARFRP1 to the Golgi apparatus (Behnia et al., 2004 [PubMed 15077113]).[supplied by OMIM, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243918
  • ENSP00000243918
  • ENSG00000204070
  • ENST00000372727
  • ENSP00000361812
  • ENST00000426004
  • ENSP00000416506

Symbol
  • C20orf169
  • C20orf169
  • dJ453C12.4
  • dJ453C12.4.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.8
transcription factor perturbation
0.8
tissue sample
0.71
transcription factor binding site profile
0.7
disease perturbation
0.68


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.56   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.56   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SYS1, golgi trafficking protein
VGNC:14305
458280
Mouse
MGI:1913710
66460
Rat
RGD:1583224
685079
Dog
SYS1, golgi trafficking protein
VGNC:54736
485894
Horse
SYS1, golgi trafficking protein
100070943
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SYS1, golgi trafficking protein
Mouse
Rat
Dog
SYS1, golgi trafficking protein
Horse
SYS1, golgi trafficking protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N2H4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Retrograde transport at the Trans-Golgi-Network
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Retrograde transport at the Trans-Golgi-Network
Vesicle-mediated transport
Protein-Protein Interactions (97)
1 – 10 of 97
SSX3
Tdark
Novelty: 0.2308992
p_int: 0.999999888
p_ni: 6.4e-8
p_wrong: 4.8e-8
Data Source: BioPlex
FAIM
Tbio
Novelty: 0.02606594
p_int: 0.99913246
p_ni: 0.000863065
p_wrong: 0.000004475
Data Source: BioPlex
S100A7
Tbio
Novelty: 0.00434262
p_int: 0.986586407
p_ni: 0.013413593
Data Source: BioPlex
ANKRD13D
Tdark
Novelty: 2.14380936
p_int: 0.978054496
p_ni: 0.021921
p_wrong: 0.000024504
Data Source: BioPlex
REEP6
Tbio
Novelty: 0.10645981
p_int: 0.933582391
p_ni: 0.066414177
p_wrong: 0.000003432
Data Source: BioPlex
UQCC1
Tbio
Family: Enzyme
Novelty: 0.03937066
p_int: 0.932961408
p_ni: 0.06703859
p_wrong: 2e-9
Data Source: BioPlex
COX6B1
Tbio
Family: Enzyme
Novelty: 0.02531055
p_int: 0.867827889
p_ni: 0.131224296
p_wrong: 0.000947815
Data Source: BioPlex
REEP5
Tbio
Novelty: 0.00160455
p_int: 0.830414613
p_ni: 0.169585004
p_wrong: 3.84e-7
Data Source: BioPlex
ARFRP1
Tbio
Family: Enzyme
Novelty: 0.07011092
Score: 0.992
Data Source: Reactome,STRINGDB
RIC1
Tbio
Novelty: 0.04422709
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score  36.56

PubMed score by year
PubTator Score  3.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer