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Tbio
PYROXD2
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2

Protein Summary
Description
Probable oxidoreductase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370575
  • ENSP00000359607
  • ENSG00000119943

Symbol
  • C10orf33
  • YUEF
  • FP3420
  • C10orf33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
cellular component
0.64
tissue sample
0.64
cell type or tissue
0.62
virus perturbation
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.45   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.45   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
2
4
10
98.9
metabolite measurement
2
2
1
1.2
95.8
blood metabolite measurement
1
1
2
88.7
serum metabolite measurement
1
1
2
88.4
trimethylamine measurement
1
1
0
1
87.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
10
98.9
metabolite measurement
1
1.2
95.8
blood metabolite measurement
2
88.7
serum metabolite measurement
2
88.4
trimethylamine measurement
0
1
87.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyridine nucleotide-disulphide oxidoreductase domain 2
VGNC:9767
743419
Mouse
MGI:1921830
74580
Rat
RGD:1303232
309381
Dog
pyridine nucleotide-disulphide oxidoreductase domain 2
VGNC:45229
100856193
Horse
pyridine nucleotide-disulphide oxidoreductase domain 2
VGNC:22068
100070628
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyridine nucleotide-disulphide oxidoreductase domain 2
Mouse
Rat
Dog
pyridine nucleotide-disulphide oxidoreductase domain 2
Horse
pyridine nucleotide-disulphide oxidoreductase domain 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N2H3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (33)
1 – 10 of 33
APPBP2
Tbio
Novelty:  0.14742368
Score:  0.723
Data Source:  STRINGDB
THEM4
Tbio
Family:  Enzyme
Novelty:  0.0191855
Score:  0.721
Data Source:  STRINGDB
NAT8
Tbio
Family:  Enzyme
Novelty:  0.02178437
Score:  0.654
Data Source:  STRINGDB
FDFT1
Tchem
Family:  Enzyme
Novelty:  0.00225882
Score:  0.604
Data Source:  STRINGDB
AGXT2
Tbio
Family:  Enzyme
Novelty:  0.02018289
Score:  0.585
Data Source:  STRINGDB
ARHGEF38
Tdark
Novelty:  0.4926213
Score:  0.58
Data Source:  STRINGDB
UGT3A1
Tdark
Family:  Enzyme
Novelty:  0.21988583
Score:  0.555
Data Source:  STRINGDB
ZDHHC16
Tbio
Family:  Enzyme
Novelty:  0.25774744
Score:  0.547
Data Source:  STRINGDB
ETNPPL
Tbio
Family:  Enzyme
Novelty:  0.11207676
Score:  0.546
Data Source:  STRINGDB
TCAF2
Tbio
Family:  Enzyme
Novelty:  0.37070492
Score:  0.537
Data Source:  STRINGDB
Publication Statistics
PubMed Score  6.45

PubMed score by year
PubTator Score  3.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer