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Tbio
LYPD1
Ly6/PLAUR domain-containing protein 1

Protein Summary
Description
Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345008
  • ENSP00000340563
  • ENSG00000150551
  • ENST00000397463
  • ENSP00000380605

Symbol
  • LYPDC1
  • PHTS
  • LYPDC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.84
transcription factor perturbation
0.8
small molecule perturbation
0.73
PubMedID
0.67
transcription factor
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.19   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.19   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Protein-Protein Interactions (119)
1 – 10 of 119
SPINK7
Tbio
Family: Enzyme
Novelty: 0.02397234
p_int: 0.999993468
p_ni: 2.1e-8
p_wrong: 0.000006511
Score: 0.175
Data Source: BioPlex,STRINGDB
SPSB3
Tdark
Novelty: 0.07215887
p_int: 0.999784831
p_ni: 0.000215085
p_wrong: 8.3e-8
Score: 0.185
Data Source: BioPlex,STRINGDB
VWDE
Tdark
Novelty: 0.37298162
p_int: 0.996509391
p_ni: 0.000388358
p_wrong: 0.003102251
Score: 0.169
Data Source: BioPlex,STRINGDB
PCSK5
Tchem
Family: Enzyme
Novelty: 0.00070772
p_int: 0.989888153
p_ni: 0.010111835
p_wrong: 1.2e-8
Score: 0.313
Data Source: BioPlex,STRINGDB
NPTX1
Tbio
Novelty: 0.02872516
p_int: 0.9880076
p_ni: 0.011992399
p_wrong: 1e-9
Score: 0.24
Data Source: BioPlex,STRINGDB
TUBA4A
Tchem
Novelty: 0.00820546
p_int: 0.955361954
p_ni: 0.044638044
p_wrong: 2e-9
Data Source: BioPlex
TUBA1A
Tchem
Novelty: 0.01030145
p_int: 0.954005997
p_ni: 0.045994003
Data Source: BioPlex
EOGT
Tbio
Family: Enzyme
Novelty: 0.08290891
p_int: 0.946964864
p_ni: 0.040140395
p_wrong: 0.012894741
Score: 0.22
Data Source: BioPlex,STRINGDB
WNT5A
Tbio
Novelty: 0.00125563
p_int: 0.924104878
p_ni: 0.075870004
p_wrong: 0.000025117
Score: 0.568
Data Source: BioPlex,STRINGDB
ZNF146
Tbio
Family: TF
Novelty: 0.05977172
p_int: 0.906199938
p_ni: 0.093789568
p_wrong: 0.000010494
Score: 0.185
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  9.19

PubMed score by year
PubTator Score  47.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer