Tbio UNC80 Protein unc-80 homolog

Protein Summary

Description

Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular calcium. The protein encoded by this gene is a component of a voltage-independent 'leak' ion-channel complex, in which it performs essential functions, such as serving as a bridge between two other components (sodium leak channel non-selective and UNC79) and as a scaffold for Src kinases. Leak channels play an importnat role in establishment and maintenance of resting membrane potentials in neurons. Mutations in this gene are associated with congenital infantile encephalopathy, intellectual disability and growth issues. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• Q8N2C7
• B2RN50
• B4DQY9
• B4DZB3
• C4IXS8
• C9J1U3
• Q96JI4
• Q96SS0

Gene Name

• UNC80

Ensembl ID

• ENST00000272845
• ENSP00000272845
• ENSG00000144406
• ENST00000439458
• ENSP00000391088

Symbol

• C2orf21
• KIAA1843
• UNC-80
• C2orf21

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.87
interacting protein	0.77
cell line	0.61
virus perturbation	0.59
gene perturbation	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.55   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 49   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.55   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0