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Tbio
PLD6
Mitochondrial cardiolipin hydrolase

Protein Summary
Description
Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol (PubMed:21397848). Has been shown to be a backbone-non-specific, single ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321560
  • ENSP00000317177
  • ENSG00000179598

Symbol
  • ZUC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
metabolite
0.78
cell type or tissue
0.72
biological process
0.67
molecular function
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.67   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.67   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
MICB
Tbio
Novelty:  0.00364639
p_int:  0.999232496
p_ni:  0.000742327
p_wrong:  0.000025176
Data Source:  BioPlex
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.998324465
p_ni:  0.001673472
p_wrong:  0.000002062
Data Source:  BioPlex
KCNC4
Tclin
Family:  IC
Novelty:  0.01215128
p_int:  0.997816815
p_ni:  0.001784407
p_wrong:  0.000398778
Data Source:  BioPlex
JMJD8
Tbio
Novelty:  0.31175159
p_int:  0.996656661
p_ni:  0.000656764
p_wrong:  0.002686575
Data Source:  BioPlex
PEX19
Tbio
Novelty:  0.00605342
p_int:  0.995530481
p_ni:  0.003702979
p_wrong:  0.00076654
Data Source:  BioPlex
SLC9A6
Tbio
Family:  Transporter
Novelty:  0.01410234
p_int:  0.994531811
p_ni:  0.005242343
p_wrong:  0.000225846
Score:  0.18
Data Source:  BioPlex,STRINGDB
SFN
Tbio
Novelty:  0.00340233
p_int:  0.994238468
p_ni:  0.005275968
p_wrong:  0.000485565
Score:  0.253
Data Source:  BioPlex,STRINGDB
IL27RA
Tbio
Novelty:  0.01348051
p_int:  0.989317291
p_ni:  0.010445886
p_wrong:  0.000236824
Data Source:  BioPlex
PCBP3
Tbio
Novelty:  0.11681812
p_int:  0.96558937
p_ni:  0.034407066
p_wrong:  0.000003564
Data Source:  BioPlex
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.962207829
p_ni:  0.000906496
p_wrong:  0.036885675
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
74
mean reticulocyte volume
1
1
1
72.2
hemoglobin measurement
2
2
2
61.8
neutrophil percentage of leukocytes
1
1
1
31.4
hematocrit
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
74
mean reticulocyte volume
1
72.2
hemoglobin measurement
2
61.8
neutrophil percentage of leukocytes
1
31.4
hematocrit
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase D family member 6
VGNC:12597
454471
Macaque
phospholipase D family member 6
703931
Mouse
MGI:2687283
194908
Rat
RGD:1311987
287366
Dog
phospholipase D family member 6
VGNC:53434
489545
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase D family member 6
Macaque
phospholipase D family member 6
Mouse
Rat
Dog
phospholipase D family member 6
Publication Statistics
PubMed Score 35.67
PubMed score by year
PubTator Score 7.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title