Tbio PLD6 Mitochondrial cardiolipin hydrolase

Protein Summary

Description

Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol (PubMed:21397848). Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity. Produces 5' phosphate and 3' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Also acts as a regulator of mitochondrial shape through facilitating mitochondrial fusion (PubMed:17028579, PubMed:26711011).

Uniprot Accession IDs

• Q8N2A8
• Q8N5Y1

Gene Name

• PLD6

Ensembl ID

• ENST00000321560
• ENSP00000317177
• ENSG00000179598

Symbol

• ZUC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
metabolite	0.78
cell type or tissue	0.72
biological process	0.67
molecular function	0.67

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Endoribonuclease / Mitochondrial Cardiolipin Hydrolase

Protein / Nucleic Acid Binding / Rna Binding Protein / Endoribonuclease / Mitochondrial Cardiolipin Hydrolase

Protein / Hydrolase / Lipase / Phospholipase / Mitochondrial Cardiolipin Hydrolase

DTO Classes

Protein / Enzyme / Hydrolase / Lipase / Phospholipase / Mitochondrial Cardiolipin Hydrolase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.02   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 81   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.02   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0