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Tbio
ARHGAP24
Rho GTPase-activating protein 24

Protein Summary
Description
Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternati ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264343
  • ENSP00000264343
  • ENSG00000138639
  • ENST00000395183
  • ENSP00000378610
  • ENST00000395184
  • ENSP00000378611
  • ENST00000503995
  • ENSP00000423206

Symbol
  • FILGAP
  • p73
  • FILGAP
  • RCGAP72
  • RC-GAP72
  • p73RhoGAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.86
virus perturbation
0.85
transcription factor perturbation
0.8
phenotype
0.79
microRNA
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.58   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.58   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Protein-Protein Interactions (89)
1 – 10 of 89
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.969
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.958
Data Source:  STRINGDB
RHOD
Tbio
Family:  Enzyme
Novelty:  0.0029764
Score:  0.939
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.938
Data Source:  STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
Score:  0.937
Data Source:  STRINGDB
RHOB
Tbio
Family:  Enzyme
Novelty:  0.0019205
Score:  0.935
Data Source:  STRINGDB
RHOJ
Tbio
Family:  Enzyme
Novelty:  0.01217051
Score:  0.934
Data Source:  STRINGDB
RHOU
Tbio
Family:  Enzyme
Novelty:  0.01456329
Score:  0.932
Data Source:  STRINGDB
RHOG
Tbio
Family:  Enzyme
Novelty:  0.00412327
Score:  0.932
Data Source:  STRINGDB
RHOQ
Tbio
Family:  Enzyme
Novelty:  0.00562425
Score:  0.929
Data Source:  STRINGDB
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
2
2
25
8.5
93.3
PR interval
6
6
0
1.9
91.2
heel bone mineral density
3
2
5
90.6
QT interval
1
1
0
8.5
68.3
heart rate
1
1
0
8.5
68.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
25
8.5
93.3
PR interval
0
1.9
91.2
heel bone mineral density
5
90.6
QT interval
0
8.5
68.3
heart rate
0
8.5
68.3
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 24
VGNC:566
461357
Macaque
Rho GTPase activating protein 24
699614
Mouse
MGI:1922647
231532
Rat
RGD:1306669
305156
Dog
Rho GTPase activating protein 24
VGNC:38053
478463
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 24
Macaque
Rho GTPase activating protein 24
Mouse
Rat
Dog
Rho GTPase activating protein 24
Publication Statistics
PubMed Score 26.58
PubMed score by year
PubTator Score 17.77
PubTator score by year