You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
SCML4
Sex comb on midleg-like protein 4

Protein Summary
Description
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369020
  • ENSP00000358016
  • ENSG00000146285
  • ENST00000369021
  • ENSP00000358017
  • ENST00000369022
  • ENSP00000358018

Symbol
  • dJ47M23.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
microRNA
0.78
protein domain
0.73
cell type or tissue
0.65
tissue sample
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.28   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.28   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
p_int:  0.999918582
p_ni:  0.000081418
Score:  0.231
Data Source:  BioPlex,STRINGDB
KDM5C
Tchem
Family:  TF; Epigenetic
Novelty:  0.00701855
p_int:  0.999674973
p_ni:  0.000324362
p_wrong:  6.65e-7
Score:  0.274
Data Source:  BioPlex,STRINGDB
FBXO11
Tbio
Novelty:  0.02762674
p_int:  0.999351016
p_ni:  0.000648982
p_wrong:  2e-9
Score:  0.217
Data Source:  BioPlex,STRINGDB
ZNF367
Tbio
Family:  TF
Novelty:  0.27340562
Score:  0.736
Data Source:  STRINGDB
LRRC61
Tdark
Novelty:  1.45343096
Score:  0.619
Data Source:  STRINGDB
ACTR3C
Tdark
Novelty:  0.16443513
Score:  0.531
Data Source:  STRINGDB
ODF3B
Tdark
Novelty:  0.2577355
Score:  0.519
Data Source:  STRINGDB
PIWIL3
Tbio
Novelty:  0.08705179
Score:  0.51
Data Source:  STRINGDB
ZNF831
Tdark
Family:  TF
Novelty:  0.64873498
Score:  0.508
Data Source:  STRINGDB
ZNF560
Tdark
Family:  TF
Novelty:  2.04576043
Score:  0.496
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
3
4
95.1
lymphocyte percentage of leukocytes
2
3
3
90.8
neutrophil percentage of leukocytes
2
3
3
73.8
heel bone mineral density
2
1
2
69.3
hemoglobin measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
95.1
lymphocyte percentage of leukocytes
3
90.8
neutrophil percentage of leukocytes
3
73.8
heel bone mineral density
2
69.3
hemoglobin measurement
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Scm polycomb group protein like 4
VGNC:48954
738923
Macaque
Scm polycomb group protein like 4
698735
Mouse
MGI:2446140
268297
Rat
RGD:1310898
309859
Dog
Scm polycomb group protein like 4
VGNC:45912
481951
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Scm polycomb group protein like 4
Macaque
Scm polycomb group protein like 4
Mouse
Rat
Dog
Scm polycomb group protein like 4
Publication Statistics
PubMed Score 1.28
PubMed score by year
PubTator Score 0.28
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title