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Tbio
INTS1
Integrator complex subunit 1

Protein Classes
Protein Summary
Description
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.78
interacting protein
0.67
protein complex
0.67
histone modification site profile
0.65
tissue sample
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive inhibition measurement
1
1
0
9.3
2.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive inhibition measurement
0
9.3
2.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915760
68510
Dog
integrator complex subunit 1
VGNC:42045
100685475
Horse
integrator complex subunit 1
VGNC:19085
100053529
Cow
integrator complex subunit 1
VGNC:30223
790146
Pig
integrator complex subunit 1
100523779
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
integrator complex subunit 1
Horse
integrator complex subunit 1
Cow
integrator complex subunit 1
Pig
integrator complex subunit 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N201-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Gene Ontology Terms (8)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (159)
1 – 10 of 159
INTS12
Tbio
Family:  Epigenetic
Novelty:  0.09023473
p_int:  0.999974777
p_ni:  0.000025222
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
TMEM130
Tdark
Novelty:  1.39618601
p_int:  0.986496958
p_ni:  0.013503042
Data Source:  BioPlex
ALDH3A2
Tbio
Family:  Enzyme
Novelty:  0.0059198
p_int:  0.965882608
p_ni:  0.034117392
Score:  0.527
Data Source:  BioPlex,STRINGDB
MGARP
Tbio
Novelty:  0.02883753
p_int:  0.961298407
p_ni:  0.038701593
Data Source:  BioPlex
TGOLN2
Tbio
Novelty:  0.005107
p_int:  0.953234468
p_ni:  0.046765532
Data Source:  BioPlex
JTB
Tbio
Novelty:  0.06646216
p_int:  0.952822963
p_ni:  0.047177037
Data Source:  BioPlex
OSTM1
Tbio
Novelty:  0.03033192
p_int:  0.952077646
p_ni:  0.047922354
p_wrong:  1e-9
Data Source:  BioPlex
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.949973227
p_ni:  0.050026773
Data Source:  BioPlex
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
p_int:  0.944332985
p_ni:  0.055667003
p_wrong:  1.2e-8
Data Source:  BioPlex
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.943957846
p_ni:  0.056042154
Data Source:  BioPlex
Publication Statistics
PubMed Score  7.00

PubMed score by year
PubTator Score  1.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer