Tbio ARHGEF28 Rho guanine nucleotide exchange factor 28

Protein Summary

Description

Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• Q8N1W1
• B2RXG7
• B4E3K4
• B5MDA3
• B7ZW32
• E9PC75
• Q8NCM7
• Q96E37
• Q9H6L3
• Q9H6W0

Gene Name

• ARHGEF28

Ensembl ID

• ENST00000296794
• ENSP00000296794
• ENSG00000214944
• ENST00000296799
• ENSP00000296799
• ENST00000426542
• ENSP00000412175
• ENST00000437974
• ENSP00000411459
• ENST00000513042
• ENSP00000441436
• ENST00000545377
• ENSP00000441913

Symbol

• KIAA1998
• RGNEF
• RIP2
• RGNEF
• p190RHOGEF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.86
metabolite	0.82
transcription factor perturbation	0.8
histone modification site profile	0.79
protein domain	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.69   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 27   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.69   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0