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Tbio
ARHGEF28
Rho guanine nucleotide exchange factor 28

Protein Summary
Description
Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296794
  • ENSP00000296794
  • ENSG00000214944
  • ENST00000296799
  • ENSP00000296799
  • ENST00000426542
  • ENSP00000412175
  • ENST00000437974
  • ENSP00000411459
  • ENST00000513042
  • ENSP00000441436
  • ENST00000545377
  • ENSP00000441913

Symbol
  • KIAA1998
  • RGNEF
  • RIP2
  • RGNEF
  • p190RHOGEF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
metabolite
0.82
transcription factor perturbation
0.8
histone modification site profile
0.79
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.07   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.07   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (76)
1 – 10 of 76
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.985
Data Source:  Reactome,STRINGDB
ROCK2
Tclin
Family:  Kinase
Novelty:  0.00242311
Score:  0.948
Data Source:  STRINGDB
ROCK1
Tclin
Family:  Kinase
Novelty:  0.00156045
Score:  0.946
Data Source:  STRINGDB
PTK2
Tclin
Family:  Kinase
Novelty:  0.00066622
Score:  0.923
Data Source:  Reactome,STRINGDB
RAC2
Tbio
Family:  Enzyme
Novelty:  0.00116234
Score:  0.846
Data Source:  STRINGDB
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
Score:  0.839
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.815
Data Source:  STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
Score:  0.787
Data Source:  STRINGDB
RHOD
Tbio
Family:  Enzyme
Novelty:  0.0029764
Score:  0.772
Data Source:  STRINGDB
NEFM
Tbio
Novelty:  0.00239134
Score:  0.758
Data Source:  STRINGDB
Pathways (8)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHB-mediated forward signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPHB-mediated forward signaling
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age-related hearing impairment
1
1
0
9.8
75
sex hormone-binding globulin measurement
4
2
4
70.4
C-reactive protein measurement
1
1
1
66.8
reticulocyte count
2
1
2
51.7
inflammatory biomarker measurement
1
1
0
48.1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age-related hearing impairment
0
9.8
75
sex hormone-binding globulin measurement
4
70.4
C-reactive protein measurement
1
66.8
reticulocyte count
2
51.7
inflammatory biomarker measurement
0
48.1
50.6
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1346016
110596
Rat
RGD:1307061
361882
Dog
Rho guanine nucleotide exchange factor 28
VGNC:38083
487245
Horse
Rho guanine nucleotide exchange factor 28
VGNC:15490
100073291
Opossum
Rho guanine nucleotide exchange factor 28
100013266
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
Rho guanine nucleotide exchange factor 28
Horse
Rho guanine nucleotide exchange factor 28
Opossum
Rho guanine nucleotide exchange factor 28
Publication Statistics
PubMed Score 36.07
PubMed score by year
PubTator Score 21.95
PubTator score by year