Tbio THEM5 Acyl-coenzyme A thioesterase THEM5

Protein Summary

Description

Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-chain fatty acid-CoA esters. Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin. Required for normal mitochondrial function.

Uniprot Accession IDs

• Q8N1Q8
• Q5T1C3
• Acyl-CoA thioesterase THEM5

Gene Name

• THEM5

Ensembl ID

• ENST00000368817
• ENSP00000357807
• ENSG00000196407

Symbol

• ACOT15
• ACOT15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.75
tissue sample	0.52
gene perturbation	0.5
cell type or tissue	0.46
disease	0.45

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.81   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 64   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.81   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0