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Tbio
KRT78
Keratin, type II cytoskeletal 78

Protein Summary
Description
This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304620
  • ENSP00000306261
  • ENSG00000170423
  • ENST00000359499
  • ENSP00000352479

Symbol
  • K5B
  • KB40
  • K5B
  • K78
  • Kb40
  • CK-78
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.9
cellular component
0.65
tissue sample
0.57
cell line
0.54
virus perturbation
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.79   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.79   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
2
1
0
1.1
41.6
serum gamma-glutamyl transferase measurement
1
1
1
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
0
1.1
41.6
serum gamma-glutamyl transferase measurement
1
0.6
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 78
VGNC:8456
451922
Macaque
keratin 78
698145
Dog
keratin 78
VGNC:42532
486514
Cow
keratin 78
VGNC:30740
523221
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 78
Macaque
keratin 78
Dog
keratin 78
Cow
keratin 78
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N1N4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (79)
1 – 10 of 79
KPRP
Tdark
Novelty: 0.11744927
Score: 0.963
Data Source: STRINGDB
KRT16
Tbio
Novelty: 0.00503235
Score: 0.94
Data Source: STRINGDB
KRT14
Tbio
Novelty: 0.00088743
Score: 0.938
Data Source: STRINGDB
KRT19
Tbio
Novelty: 0.00043162
Score: 0.934
Data Source: STRINGDB
KRT32
Tdark
Novelty: 1.12077627
Score: 0.932
Data Source: STRINGDB
KRT15
Tbio
Novelty: 0.00351898
Score: 0.932
Data Source: STRINGDB
KRT17
Tbio
Novelty: 0.00278761
Score: 0.931
Data Source: STRINGDB
KRT35
Tbio
Novelty: 0.01111091
Score: 0.93
Data Source: STRINGDB
KRT36
Tdark
Novelty: 0.50578568
Score: 0.93
Data Source: STRINGDB
KRT10
Tbio
Novelty: 0.00166073
Score: 0.929
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.79

PubMed score by year
PubTator Score  19.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer