Protein Summary
Forms calcium-sensitive chloride channels. Permeable to bicarbonate. BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM, Mar 2008]
- ENST00000266661
- ENSP00000266661
- ENSG00000127325
- ENST00000330891
- ENSP00000332413
- ENST00000331471
- ENSP00000329064
- ENST00000488961
- ENSP00000433213
- ENST00000551160
- ENSP00000449377
- ENST00000553096
- ENSP00000449548
- VMD2L3
- VMD2L3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.71 | ||
transcription factor | 0.64 | ||
cell type or tissue | 0.61 | ||
cell line | 0.53 | ||
molecular function | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 46.44 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 259 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 46.44 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 259 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0